biostudies-literatureHeymsfield SBNIDDK NIH HHSNIA NIH HHSNational Institutes of HealthNIH HHSNIGMS NIH HHS32-40https://www.ebi.ac.uk/biostudies/studies/S-EPMC10872987biostudies-literatureUnknown32(1)<h4>Objective</h4>This study's objective was to develop models predicting the relative reduction in skeletal muscle (SM) mass during periods of voluntary calorie restriction (CR) and to validate model predictions in longitudinally monitored samples.<h4>Methods</h4>The model development group included healthy nonexercising adults (n = 897) who had whole-body SM mass measured with magnetic resonance imaging. Model predictions of relative SM changes with CR were evaluated in two longitudinal studies, one 12 to 14 weeks in duration (n = 74) and the other 12 months in duration (n = 26).<h4>Results</h4>A series of SM prediction models were developed in a sample of 415 males and 482 females. Model-predicted changes in SM mass relative to changes in body weight (i.e., ΔSM/Δbody weight) with a reprObesity (Silver Spring, Md.)Proportion of caloric restriction-induced weight loss as skeletal muscle.PMC10872987AG029914AG020480P30DK072476U54 GM104940AG020478AG020487U01 AG020480U01 AG022132P30 DK072476P30DK040561U01 AG020487P30DK26687P30 DK026687R01 AG029914U01 AG020478P30 DK040561R01AG045761R01 AG045761Redman LMRavussin EMuller MJMartin CKBosy-Westphal AHeymsfield SBYang SShen WMcCarthy CBrown JBfalseProportion of caloric restriction-induced weight loss as skeletal muscle.<h4>Objective</h4>This study's objective was to develop models predicting the relative reduction in skeletal muscle (SM) mass during periods of voluntary calorie restriction (CR) and to validate model predictions in longitudinally monitored samples.<h4>Methods</h4>The model development group included healthy nonexercising adults (n = 897) who had whole-body SM mass measured with magnetic resonance imaging. Model predictions of relative SM changes with CR were evaluated in two longitudinal studies, one 12 to 14 weeks in duration (n = 74) and the other 12 months in duration (n = 26).<h4>Results</h4>A series of SM prediction models were developed in a sample of 415 males and 482 females. Model-predicted changes in SM mass relative to changes in body weight (i.e., ΔSM/Δbody weight) with a repr2024-01-01T00:00:00Z2024 Jan2026-06-02T17:59:00.175Z2026-04-18T03:12:12.137ZS-EPMC108729873780715410.1002/oby.23910