{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["331(9)"],"submitter":["Bakris GL"],"pubmed_abstract":["<h4>Importance</h4>Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis.<h4>Objective</h4>To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens.<h4>Design, setting, and participants</h4>This phase 2, randomized, double-blind, dose-ranging study of zilebesiran vs placebo was performed at 78 sites across 4 countries. Screening initiation occurred in July 2021 and the last patient visit of the 6-month study occurred in June 2023. Adults with mild to moderate hypertension, defined as daytime mean ambulatory systolic BP (SBP) of 135 to 160 mm Hg following antihypertensiv"],"journal":["JAMA"],"pagination":["740-749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10873804"],"repository":["biostudies-literature"],"pubmed_title":["RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial."],"pmcid":["PMC10873804"],"pubmed_authors":["Patton S","Fylenko Y","McGill L","Mondoc N","Bailey G","West N","Quenneville L","Mauri M","Merrick A","Novotny E","Coreas D","McElheney M","Kendall T","Leone S","Tagsip M","Villarreal S","Santana C","Chalhoub F","Ramirez R","Castello J","Blanchard J","Rioux S","Viljoen M","Blubaugh H","Russell S","Arnold V","Culbreth E","Heredia G","Rioux J","Clowes J","Rafuse A","Van Camp D","Worthen I","Yu D","Wahaj Z","Averett A","Krambeck E","Venereo J","Radchenko O","Cortes-Maisonet G","Ramirez C","Tyler K","Shalala 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Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial.","description":"<h4>Importance</h4>Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis.<h4>Objective</h4>To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens.<h4>Design, setting, and participants</h4>This phase 2, randomized, double-blind, dose-ranging study of zilebesiran vs placebo was performed at 78 sites across 4 countries. Screening initiation occurred in July 2021 and the last patient visit of the 6-month study occurred in June 2023. Adults with mild to moderate hypertension, defined as daytime mean ambulatory systolic BP (SBP) of 135 to 160 mm Hg following antihypertensiv","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-01T16:25:41.688Z","creation":"2024-11-09T15:40:46.63Z"},"accession":"S-EPMC10873804","cross_references":{"pubmed":["38363577"],"doi":["10.1001/jama.2024.0728"]}}