biostudies-literatureUnknownMessina JAParker Institute for Cancer ImmunotherapyMSK Cancer CenterNational University of Singapore DevelopmentNIA NIH HHSNIAID NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNational Cancer InstituteNCI NIH HHSNational Institutes of HealthNational Institute on Aging<h4>Background</h4>Enterococcus intestinal domination (EID), a state of dysbiosis wherein enterococci comprise ≥30% abundance within the microbiota, has been associated with Enterococcus bacteremia, graft-versus-host disease, and mortality in the allogeneic hematopoietic stem cell transplant (allo HCT) population. The acute leukemia (AL) chemotherapy population includes patients receiving intensive chemotherapy but do not all go on to have an allo HCT. The impact of EID on outcomes including mortality in the AL chemotherapy population is unknown.<h4>Methods</h4>Microbiota composition from weekly stool samples was analyzed by 16S ribosomal RNA gene sequencing. Patients were analyzed in 2 cohorts: AL chemotherapy cohort and allo HCT cohort. Alpha-diversity and richness were calculated. KaplaClinical infectious diseases : an official publication of the Infectious Diseases Society of Americaciab1043https://www.ebi.ac.uk/biostudies/studies/S-EPMC10874263biostudies-literatureEnterococcus Intestinal Domination is Associated with Increased Mortality in the Acute Leukemia Chemotherapy Population.PMC10874263P01-CA023766P01-AG052359P30 CA008748R01 HL123340K08HL143189K23 AI163365R21 AG066388R01 HL147584R01-R01-HL147584P01 AG052359R21AG066388T32 AI100851R01-CA228308,P01 CA023766K08 HL143189R01-CA228358R01-HL123340R01 CA228308R01 CA228358Messina JASung ADvan den Brink MRMRen YGomes APeled JUChao NJBush AAndermann TTan CYLew MSurana NKHill LfalseEnterococcus Intestinal Domination is Associated with Increased Mortality in the Acute Leukemia Chemotherapy Population.<h4>Background</h4>Enterococcus intestinal domination (EID), a state of dysbiosis wherein enterococci comprise ≥30% abundance within the microbiota, has been associated with Enterococcus bacteremia, graft-versus-host disease, and mortality in the allogeneic hematopoietic stem cell transplant (allo HCT) population. The acute leukemia (AL) chemotherapy population includes patients receiving intensive chemotherapy but do not all go on to have an allo HCT. The impact of EID on outcomes including mortality in the AL chemotherapy population is unknown.<h4>Methods</h4>Microbiota composition from weekly stool samples was analyzed by 16S ribosomal RNA gene sequencing. Patients were analyzed in 2 cohorts: AL chemotherapy cohort and allo HCT cohort. Alpha-diversity and richness were calculated. Kapla2021-01-01T00:00:00Z2021 Dec2026-06-12T03:09:13.659Z2024-11-14T13:25:04.114ZS-EPMC108742633492834110.1093/cid/ciab1043