biostudies-literatureUnknown18(2)Poursafari Talemi E<h4>Background</h4>Infertile men with multiple morphological abnormalities of the sperm flagella (MMAF) phenotype exhibit mosaic sperm flagella abnormalities such as short, bent, coiled, and irregular flagella or absent flagella. Sperm flagellum has an ultrastructurally axonemal structure that contains a large number of proteins. A-Kinase Anchoring Protein 3 (AKAP3) is expressed in spermatozoa. It may function as a regulator of motility and the acrosome reaction. This study aimed to compare genetic changes in infertile men suffering MMAF phenotype with the control group.<h4>Materials and methods</h4>In this case-control study, genetic variants of the <i>AKAP3</i> gene were evaluated in 60 infertile men with MMAF phenotype and 40 fertile men, as control. As exon five of the <i>AKAP3</i> genInternational journal of fertility & sterility180-184https://www.ebi.ac.uk/biostudies/studies/S-EPMC10875313biostudies-literatureEvaluation of The 1499T>C Variant in The <i>AKAP3</i> Gene of Infertile Men with Multiple Morphological Abnormalities of The Sperm Flagella Phenotype: A Case-Control Study.PMC10875313Hosseini SHMohseni Meybodi AGourabi HPoursafari Talemi ESabbaghian MfalseEvaluation of The 1499T>C Variant in The <i>AKAP3</i> Gene of Infertile Men with Multiple Morphological Abnormalities of The Sperm Flagella Phenotype: A Case-Control Study.<h4>Background</h4>Infertile men with multiple morphological abnormalities of the sperm flagella (MMAF) phenotype exhibit mosaic sperm flagella abnormalities such as short, bent, coiled, and irregular flagella or absent flagella. Sperm flagellum has an ultrastructurally axonemal structure that contains a large number of proteins. A-Kinase Anchoring Protein 3 (AKAP3) is expressed in spermatozoa. It may function as a regulator of motility and the acrosome reaction. This study aimed to compare genetic changes in infertile men suffering MMAF phenotype with the control group.<h4>Materials and methods</h4>In this case-control study, genetic variants of the <i>AKAP3</i> gene were evaluated in 60 infertile men with MMAF phenotype and 40 fertile men, as control. As exon five of the <i>AKAP3</i> gen2024-01-01T00:00:00Z2024 Feb2025-04-05T14:43:53.1Z2025-04-05T14:43:53.1ZS-EPMC108753133836852310.22074/ijfs.2023.561016.1358