{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gorchs L"],"funding":["Cancerföreningen i Stockholm (Cancer Society in Stockholm)","Insamlingsstiftelsen Cancer- och Allergifonden (Cancer and Allergy Fund)","Insamlingsstiftelsen Cancer- och Allergifonden","Swedish Cancer Foundation","Ruth och Richard Julins Stiftelse (Ruth and Richard Julin Foundation)","Cancerföreningen i Stockholm","Ruth och Richard Julins Stiftelse"],"pagination":["460-474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10875982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(2)"],"pubmed_abstract":["In pancreatic ductal adenocarcinoma, the infiltration of CD8+ T cells within the tumor microenvironment correlates with a favorable prognosis. However, a significant proportion of tumor-infiltrating T cells become trapped within the desmoplastic stroma and lack tumor reactivity. Here, we explored different T-cell subsets in pancreatic tumors and adjacent tissues. We identified a subset of CD8+ T cells, double positive (DP) for CD39 and CD103 in pancreatic tumors, which has recently been described to display tumor reactivity in other types of solid tumors. Interestingly, DP CD8+ T cells preferentially accumulated in central tumor tissues compared with paired peripheral tumor and adjacent non-tumor tissues. Consistent with an antigen encounter, DP CD8+ T cells demonstrated higher proliferati"],"journal":["Cancer research communications"],"pubmed_title":["Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer."],"pmcid":["PMC10875982"],"funding_grant_id":["10679","20 1162 PjF","2022-00285","221173","201152","10388"],"pubmed_authors":["Lohr MJ","Asplund E","Gorchs L","Solders M","Sparrelid E","Kaipe H","Ghorbani P","Oosthoek M","Fernandez-Moro C","Rangelova E"],"additional_accession":[]},"is_claimable":false,"name":"Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.","description":"In pancreatic ductal adenocarcinoma, the infiltration of CD8+ T cells within the tumor microenvironment correlates with a favorable prognosis. However, a significant proportion of tumor-infiltrating T cells become trapped within the desmoplastic stroma and lack tumor reactivity. Here, we explored different T-cell subsets in pancreatic tumors and adjacent tissues. We identified a subset of CD8+ T cells, double positive (DP) for CD39 and CD103 in pancreatic tumors, which has recently been described to display tumor reactivity in other types of solid tumors. Interestingly, DP CD8+ T cells preferentially accumulated in central tumor tissues compared with paired peripheral tumor and adjacent non-tumor tissues. Consistent with an antigen encounter, DP CD8+ T cells demonstrated higher proliferati","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-05-29T12:11:01.044Z","creation":"2025-04-04T14:00:59.058Z"},"accession":"S-EPMC10875982","cross_references":{"pubmed":["38335302"],"doi":["10.1158/2767-9764.CRC-23-0405"]}}