biostudies-literatureGorchs LCancerföreningen i Stockholm (Cancer Society in Stockholm)Insamlingsstiftelsen Cancer- och Allergifonden (Cancer and Allergy Fund)Insamlingsstiftelsen Cancer- och AllergifondenSwedish Cancer FoundationRuth och Richard Julins Stiftelse (Ruth and Richard Julin Foundation)Cancerföreningen i StockholmRuth och Richard Julins Stiftelse460-474https://www.ebi.ac.uk/biostudies/studies/S-EPMC10875982biostudies-literatureUnknown4(2)In pancreatic ductal adenocarcinoma, the infiltration of CD8+ T cells within the tumor microenvironment correlates with a favorable prognosis. However, a significant proportion of tumor-infiltrating T cells become trapped within the desmoplastic stroma and lack tumor reactivity. Here, we explored different T-cell subsets in pancreatic tumors and adjacent tissues. We identified a subset of CD8+ T cells, double positive (DP) for CD39 and CD103 in pancreatic tumors, which has recently been described to display tumor reactivity in other types of solid tumors. Interestingly, DP CD8+ T cells preferentially accumulated in central tumor tissues compared with paired peripheral tumor and adjacent non-tumor tissues. Consistent with an antigen encounter, DP CD8+ T cells demonstrated higher proliferatiCancer research communicationsExhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.PMC108759821067920 1162 PjF2022-0028522117320115210388Lohr MJAsplund EGorchs LSolders MSparrelid EKaipe HGhorbani POosthoek MFernandez-Moro CRangelova EfalseExhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.In pancreatic ductal adenocarcinoma, the infiltration of CD8+ T cells within the tumor microenvironment correlates with a favorable prognosis. However, a significant proportion of tumor-infiltrating T cells become trapped within the desmoplastic stroma and lack tumor reactivity. Here, we explored different T-cell subsets in pancreatic tumors and adjacent tissues. We identified a subset of CD8+ T cells, double positive (DP) for CD39 and CD103 in pancreatic tumors, which has recently been described to display tumor reactivity in other types of solid tumors. Interestingly, DP CD8+ T cells preferentially accumulated in central tumor tissues compared with paired peripheral tumor and adjacent non-tumor tissues. Consistent with an antigen encounter, DP CD8+ T cells demonstrated higher proliferati2024-01-01T00:00:00Z2024 Feb2026-05-29T12:11:01.044Z2025-04-04T14:00:59.058ZS-EPMC108759823833530210.1158/2767-9764.CRC-23-0405