biostudies-literatureUnknown35Liu XFundamental Research Funds for the Central UniversitiesInnovative Research Team of High-level Local Universities in ShanghaiNational Natural Science Foundation of ChinaThe impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation. Under local mechanical stress, the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells (PDLSCs) via modulating energy metabolism and promoting adenosine triphosphate (ATP) synthesis. Moreover, it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype. The synergy of tilapia gelatin and piezoelectric stimulation enhancesBioactive materials346-361https://www.ebi.ac.uk/biostudies/studies/S-EPMC10876489biostudies-literaturePiezoelectric hydrogel for treatment of periodontitis through bioenergetic activation.PMC10876489Liu XSui BLiu ZDing TChen YWan XHu QZhao JLi LWang ZLfalsePiezoelectric hydrogel for treatment of periodontitis through bioenergetic activation.The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation. Under local mechanical stress, the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells (PDLSCs) via modulating energy metabolism and promoting adenosine triphosphate (ATP) synthesis. Moreover, it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype. The synergy of tilapia gelatin and piezoelectric stimulation enhances2024-01-01T00:00:00Z2024 May2025-04-22T11:09:59.243Z2025-04-05T23:51:03.709ZS-EPMC108764893837969910.1016/j.bioactmat.2024.02.011