{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Perez-Jurado LA"],"pubmed_abstract":["The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LO"],"journal":["Communications biology"],"pagination":["202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10876565"],"repository":["biostudies-literature"],"pubmed_title":["Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2."],"pmcid":["PMC10876565"],"pubmed_authors":["de la Horra C","Andreu-Bernabeu A","Lopez-Ruz MA","Rodriguez-Urrego PA","Cuesta L","Valencia-Ramos J","Brion M","Dantas-Komatsu RCS","Rodriguez-Ferrer M","Rodriguez-Garcia JA","Souza VS","Rodriguez-Gallego C","Diaz-Perez A","Munoz Garcia P","Rodriguez-Novoa GE","Padilla-Conejo I","Horcajada JP","Mejuto-Montero N","Santos A","Ruiz-Cubillan JJ","Teper A","Heili-Frades S","Pariente-Rodriguez R","Schluter A","Herrero MJ","Fernandez-Villa T","Torres-Gutierrez RP","Montoya JJ","Bernal E","Mendez-Echevarria A","Lopez-Rodriguez 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age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LO","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-02T22:44:22.439Z","creation":"2025-04-19T07:37:50.693Z"},"accession":"S-EPMC10876565","cross_references":{"pubmed":["38374351"],"doi":["10.1038/s42003-024-05805-6"]}}