biostudies-literatureUnknown200(3)Majewski W<h4>Purpose</h4>Local recurrences after radical prostatectomy (RP) and postoperative radiotherapy (RT) are challenging for salvage treatment. Retrospective analysis of own experiences with salvage re-irradiation was performed.<h4>Methods</h4>The study included all consecutive patients treated with salvage stereotactic body radiotherapy (sSBRT) for prostate bed recurrence following RP and postoperative RT at a single tertiary center between 2014 and 2021. Treatment toxicity defined as the occurrence of CTCAE grade ≥ 2 genito-urinary (GU) or gastro-intestinal (GI) adverse events (AEs) was assessed. A PSA response, biochemical control (BC) and overall survival (OS) were also evaluated.<h4>Results</h4>The study group included 32 patients with a median age of 68 years and a median follow-up of Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]230-238https://www.ebi.ac.uk/biostudies/studies/S-EPMC10876733biostudies-literatureStereotactic body radiotherapy (SBRT) re-irradiation for local failures following radical prostatectomy and post-operative radiotherapy.PMC10876733Graupner DGoc BGoldner GNapieralska AMajewski WMiszczyk MfalseStereotactic body radiotherapy (SBRT) re-irradiation for local failures following radical prostatectomy and post-operative radiotherapy.<h4>Purpose</h4>Local recurrences after radical prostatectomy (RP) and postoperative radiotherapy (RT) are challenging for salvage treatment. Retrospective analysis of own experiences with salvage re-irradiation was performed.<h4>Methods</h4>The study included all consecutive patients treated with salvage stereotactic body radiotherapy (sSBRT) for prostate bed recurrence following RP and postoperative RT at a single tertiary center between 2014 and 2021. Treatment toxicity defined as the occurrence of CTCAE grade ≥ 2 genito-urinary (GU) or gastro-intestinal (GI) adverse events (AEs) was assessed. A PSA response, biochemical control (BC) and overall survival (OS) were also evaluated.<h4>Results</h4>The study group included 32 patients with a median age of 68 years and a median follow-up of 2024-01-01T00:00:00Z2024 Mar2026-06-17T06:29:19.599Z2025-04-05T23:49:32.726ZS-EPMC108767333815701610.1007/s00066-023-02187-2