biostudies-literaturePatterson TBritish Heart FoundationNational Institute for Health and Care Research1329-1337https://www.ebi.ac.uk/biostudies/studies/S-EPMC10877072biostudies-literatureUnknown402(10410)<h4>Background</h4>The International Liaison Committee on Resuscitation has called for a randomised trial of delivery to a cardiac arrest centre. We aimed to assess whether expedited delivery to a cardiac arrest centre compared with current standard of care following resuscitated cardiac arrest reduces deaths.<h4>Methods</h4>ARREST is a prospective, parallel, multicentre, open-label, randomised superiority trial. Patients (aged ≥18 years) with return of spontaneous circulation following out-of-hospital cardiac arrest without ST elevation were randomly assigned (1:1) at the scene of their cardiac arrest by London Ambulance Service staff using a secure online randomisation system to expedited delivery to the cardiac catheter laboratory at one of seven cardiac arrest centres or standard of caLancet (London, England)Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial.PMC10877072CS/16/3/32615Pavlidis AStephens NClapp BRoberts PLane GNolan JPWragg ANijjer SWilson KDodd MPerkins AMellett-Smith APendolino VEvans RJain ARedwood SRPerera DHughes JRosser GConnor MBogle RKwok MMacCarthy PMcCrone PByrne JBlows LSpencer OChamberlain DSidney TPrendergast BLong APerkins GDRobertson SOzkor MDas RKurbaan AClayton TRakhit RJerome LWhitbread MMuir KShaw JRitches-Price JPetzer EKearney JWebb IFiroozi SCurzen NLampard AMalik IBannister CMamas MARREST trial collaboratorsMorris TMarciniak MDe Belder MPatterson TWood DBell RBrown MKnight MKhan MPalti GStables RAdamson DDalby MPapadopoulos DFothergill RTfalseExpedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial.<h4>Background</h4>The International Liaison Committee on Resuscitation has called for a randomised trial of delivery to a cardiac arrest centre. We aimed to assess whether expedited delivery to a cardiac arrest centre compared with current standard of care following resuscitated cardiac arrest reduces deaths.<h4>Methods</h4>ARREST is a prospective, parallel, multicentre, open-label, randomised superiority trial. Patients (aged ≥18 years) with return of spontaneous circulation following out-of-hospital cardiac arrest without ST elevation were randomly assigned (1:1) at the scene of their cardiac arrest by London Ambulance Service staff using a secure online randomisation system to expedited delivery to the cardiac catheter laboratory at one of seven cardiac arrest centres or standard of ca2023-01-01T00:00:00Z2023 Oct2025-04-22T11:11:45.124Z2025-04-05T23:51:40.54ZS-EPMC108770723764792810.1016/S0140-6736(23)01351-X