{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["98(2)"],"submitter":["Huang H"],"pubmed_abstract":["Porcine deltacoronavirus (PDCoV) has caused enormous economic losses to the global pig industry. However, the immune escape mechanism of PDCoV remains to be fully clarified. Transcriptomic analysis revealed a high abundance of interferon (IFN)-induced protein with tetratricopeptide repeats 3 (IFIT3) transcripts after PDCoV infection, which initially implied a correlation between IFIT3 and PDCoV. Further studies showed that PDCoV nsp5 could antagonize the host type I interferon signaling pathway by cleaving IFIT3. We demonstrated that PDCoV nsp5 cleaved porcine IFIT3 (pIFIT3) at Gln-406. Similar cleavage of endogenous IFIT3 has also been observed in PDCoV-infected cells. The pIFIT3-Q406A mutant was resistant to nsp5-mediated cleavage and exhibited a greater ability to inhibit PDCoV infectio"],"journal":["Journal of virology"],"pagination":["e0168223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10878044"],"repository":["biostudies-literature"],"pubmed_title":["Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3."],"pmcid":["PMC10878044"],"pubmed_authors":["Lan T","Li Y","Zhao C","Li C","Zhao B","Lu H","Lei X","Huang H","Zhang X","Qin Y","Jin N","Sun W"],"additional_accession":[]},"is_claimable":false,"name":"Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3.","description":"Porcine deltacoronavirus (PDCoV) has caused enormous economic losses to the global pig industry. However, the immune escape mechanism of PDCoV remains to be fully clarified. Transcriptomic analysis revealed a high abundance of interferon (IFN)-induced protein with tetratricopeptide repeats 3 (IFIT3) transcripts after PDCoV infection, which initially implied a correlation between IFIT3 and PDCoV. Further studies showed that PDCoV nsp5 could antagonize the host type I interferon signaling pathway by cleaving IFIT3. We demonstrated that PDCoV nsp5 cleaved porcine IFIT3 (pIFIT3) at Gln-406. Similar cleavage of endogenous IFIT3 has also been observed in PDCoV-infected cells. The pIFIT3-Q406A mutant was resistant to nsp5-mediated cleavage and exhibited a greater ability to inhibit PDCoV infectio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-18T06:52:27.04Z","creation":"2025-04-19T07:36:09.042Z"},"accession":"S-EPMC10878044","cross_references":{"pubmed":["38289117"],"doi":["10.1128/jvi.01682-23"]}}