{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu J"],"funding":["Key Research and Development Projects of Shaanxi Province","Thyroid Research Project of Young and Middle-aged Physicians of Beijing Bethune Charitable Foundation","The Basic Natural Science Research Program of Shaanxi Province","Natural Science Basic Research Program of Shaanxi Province","National Natural Science Foundation of China","the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University","the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University","Clinical Research Center for Thyroid Diseases of Shaanxi Province"],"pagination":["14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10879231"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(1)"],"pubmed_abstract":["<h4>Background</h4>RING Finger Protein 115 (RNF115), a notable E3 ligase, is known to modulate tumorigenesis and metastasis. In our investigation, we endeavor to unravel the putative function and inherent mechanism through which RNF115 influences the evolution of thyroid carcinoma (THCA).<h4>Methods</h4>We analyzed RNF115 expression in THCA using the Cancer Genome Atlas (TCGA) database. The influence of RNF115 on the progression of THCA was evaluated using both in vitro and in vivo experimental approaches. The protein regulated by RNF115 was identified through bioinformatics analysis, and its biological significance was further explored.<h4>Results</h4>In both THCA tissues and cells, RNF115 showed elevated expression levels. Enhanced expression of RNF115 fostered cell proliferation, tumor "],"journal":["Cell biology and toxicology"],"pubmed_title":["RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma."],"pmcid":["PMC10879231"],"funding_grant_id":["2021JQ-386","2017LCZX-03","BQE-JZX-202103","2022SF-159","2021JQ-405","82103568","XJTU1AF-CRF-2020-020"],"pubmed_authors":["Zheng Z","Li X","Guo L","Liu J","Yan J","Zhu J","Zhao Q","Xu C","Zhang S","Sun X","Dai H"],"additional_accession":[]},"is_claimable":false,"name":"RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma.","description":"<h4>Background</h4>RING Finger Protein 115 (RNF115), a notable E3 ligase, is known to modulate tumorigenesis and metastasis. In our investigation, we endeavor to unravel the putative function and inherent mechanism through which RNF115 influences the evolution of thyroid carcinoma (THCA).<h4>Methods</h4>We analyzed RNF115 expression in THCA using the Cancer Genome Atlas (TCGA) database. The influence of RNF115 on the progression of THCA was evaluated using both in vitro and in vivo experimental approaches. The protein regulated by RNF115 was identified through bioinformatics analysis, and its biological significance was further explored.<h4>Results</h4>In both THCA tissues and cells, RNF115 showed elevated expression levels. Enhanced expression of RNF115 fostered cell proliferation, tumor ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-26T08:06:22.915Z","creation":"2025-04-06T12:32:27.125Z"},"accession":"S-EPMC10879231","cross_references":{"pubmed":["38376606"],"doi":["10.1007/s10565-024-09845-w"]}}