{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hadj Mohamed A"],"funding":["Campus France","Ministère de l’Enseignement Supérieur et de la Recherche Scientifique"],"pagination":["660-676"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10880923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Triarylmethanes and triazoles constitute privileged structures extensively used in drug discovery programs. In this work, 12 novel triarylmethanes linked to a triazole ring were designed, synthesized, and chemically characterized aiming to target colorectal cancer. The synthetic strategy for triarylmethanes mono- and bi-substituted by a functionalized triazole ring involved a 1,3-dipolar cycloaddition. A preliminary screening in human colorectal cancer cells (HT-29 and HCT116) and murine primary fibroblasts (L929) allowed the selection of the best candidate 9b based on its high inhibition of cancer cell proliferation with an IC<sub>50</sub> of 11 μM on HT-29 and 14 μM on HCT116 and its non-cytotoxic effects on murine fibroblasts (<100 μM). A deep mechanistic study on various pathways showe"],"journal":["RSC medicinal chemistry"],"pubmed_title":["Colorectal anticancer activity of a novel class of triazolic triarylmethane derivatives."],"pmcid":["PMC10880923"],"funding_grant_id":["PhD scholarship 964896H (2019–20)","UTIQUE 2017 37094W","Eiffel program","PHC Program"],"pubmed_authors":["Msaddek M","Hadj Mohamed A","Lagarde N","Pinon A","Ricco C","Goya-Jorge E","Liagre B","Mouhsine H","Veitia MS"],"additional_accession":[]},"is_claimable":false,"name":"Colorectal anticancer activity of a novel class of triazolic triarylmethane derivatives.","description":"Triarylmethanes and triazoles constitute privileged structures extensively used in drug discovery programs. In this work, 12 novel triarylmethanes linked to a triazole ring were designed, synthesized, and chemically characterized aiming to target colorectal cancer. The synthetic strategy for triarylmethanes mono- and bi-substituted by a functionalized triazole ring involved a 1,3-dipolar cycloaddition. A preliminary screening in human colorectal cancer cells (HT-29 and HCT116) and murine primary fibroblasts (L929) allowed the selection of the best candidate 9b based on its high inhibition of cancer cell proliferation with an IC<sub>50</sub> of 11 μM on HT-29 and 14 μM on HCT116 and its non-cytotoxic effects on murine fibroblasts (<100 μM). A deep mechanistic study on various pathways showe","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-03T00:59:42.062Z","creation":"2025-04-06T22:29:55.526Z"},"accession":"S-EPMC10880923","cross_references":{"pubmed":["38389891"],"doi":["10.1039/d3md00467h"]}}