{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Laskou A"],"funding":["Deutsche Forschungsgemeinschaft","European Commission"],"pagination":["2287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10888570"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(4)"],"pubmed_abstract":["TFF3 is a typical secretory poplypeptide of mucous epithelia belonging to the trefoil factor family (TFF) of lectins. In the intestine, respiratory tract, and saliva, TFF3 mainly exists as a high-molecular-mass complex with IgG Fc binding protein (FCGBP), which is indicative of a role in mucosal innate immunity. For the first time, we identified different forms of TFF3 in the endocervix, i.e., monomeric and homodimeric TFF3, as well as a high-molecular-mass TFF3-FCGBP complex; the latter also exists in a hardly soluble form. Immunohistochemistry co-localized TFF3 and FCGBP. Expression analyses of endocervical and post-menopausal vaginal specimens revealed a lack of mucin and TFF3 transcripts in the vaginal specimens. In contrast, genes encoding other typical components of the innate immune"],"journal":["International journal of molecular sciences"],"pubmed_title":["Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier."],"pmcid":["PMC10888570"],"funding_grant_id":["INST 337/15-1, INST 337/16-1, INST 152/837-1 and INST 152/947-1 FUGG","ZS/2016/10/81609"],"pubmed_authors":["Matthes C","Hoffmann W","Harder S","Schluter H","Langer K","Znalesniak EB","Tchaikovski SN","Jechorek D","Strecker C","Laskou A"],"additional_accession":[]},"is_claimable":false,"name":"Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier.","description":"TFF3 is a typical secretory poplypeptide of mucous epithelia belonging to the trefoil factor family (TFF) of lectins. In the intestine, respiratory tract, and saliva, TFF3 mainly exists as a high-molecular-mass complex with IgG Fc binding protein (FCGBP), which is indicative of a role in mucosal innate immunity. For the first time, we identified different forms of TFF3 in the endocervix, i.e., monomeric and homodimeric TFF3, as well as a high-molecular-mass TFF3-FCGBP complex; the latter also exists in a hardly soluble form. Immunohistochemistry co-localized TFF3 and FCGBP. Expression analyses of endocervical and post-menopausal vaginal specimens revealed a lack of mucin and TFF3 transcripts in the vaginal specimens. In contrast, genes encoding other typical components of the innate immune","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-22T13:26:27.994Z","creation":"2025-02-19T01:38:28.202Z"},"accession":"S-EPMC10888570","cross_references":{"pubmed":["38396964"],"doi":["10.3390/ijms25042287"]}}