biostudies-literatureUnknown13(4)De Simone P<h4>Background</h4>In Italy, data on long-term survivors after liver transplantation are lacking.<h4>Materials and methods</h4>We conducted a hybrid design study on a cohort of 359 adult recipients who received transplants between 1996 and 2002 to identify predictors of survival and the prevalence of co-morbidities among long-term survivors.<h4>Results</h4>The actuarial (95% CI) patient survival was 96% (94.6-98.3%), 69% (64.2-73.6%), 55% (49.8-59.9%), 42.8% (37.6-47.8%), and 34% (29.2-38.9%) at 1, 5, 10, 15, and 20 years, respectively. The leading causes of death were hepatitis C virus recurrence (24.6%), extrahepatic malignancies (16.9%), infection (14.4%), and hepatocellular carcinoma recurrence (14.4%). The factors associated with the survival probability were younger donor and recipieJournal of clinical medicine1087https://www.ebi.ac.uk/biostudies/studies/S-EPMC10889074biostudies-literatureAging with a Liver Graft: Analysis of Very Long-Term Survivors after Liver Transplantation.PMC10889074Gitto SDucci JMarchetti PCampani DMartinelli CDe Simone PBiancofiore GBronzoni JfalseAging with a Liver Graft: Analysis of Very Long-Term Survivors after Liver Transplantation.<h4>Background</h4>In Italy, data on long-term survivors after liver transplantation are lacking.<h4>Materials and methods</h4>We conducted a hybrid design study on a cohort of 359 adult recipients who received transplants between 1996 and 2002 to identify predictors of survival and the prevalence of co-morbidities among long-term survivors.<h4>Results</h4>The actuarial (95% CI) patient survival was 96% (94.6-98.3%), 69% (64.2-73.6%), 55% (49.8-59.9%), 42.8% (37.6-47.8%), and 34% (29.2-38.9%) at 1, 5, 10, 15, and 20 years, respectively. The leading causes of death were hepatitis C virus recurrence (24.6%), extrahepatic malignancies (16.9%), infection (14.4%), and hepatocellular carcinoma recurrence (14.4%). The factors associated with the survival probability were younger donor and recipie2024-01-01T00:00:00Z2024 Feb2025-04-19T14:49:05.525Z2025-04-19T14:49:05.525ZS-EPMC108890743839840010.3390/jcm13041087