{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ismail J"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10891717"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(2)"],"pubmed_abstract":["Hybrid nanoparticles (HNPs) were designed by combining a PLGA core with a lipid shell that incorporated PEG-Lipid conjugates with various functionalities (-RGD, -cRGD, -NH<sub>2</sub>, and -COOH) to create targeted drug delivery systems. Loaded with a neutral lipid orange dye, the HNPs were extensively characterized using various techniques and investigated for their uptake in human monocyte-derived macrophages (MDMs) using FC and CLSM. Moreover, the best-performing HNPs (i.e., HNP-COOH and HNP-RGD as well as HNP-RGD/COOH mixed) were loaded with the anti-inflammatory drug BRP-201 and prepared in two size ranges (d<sub>H</sub> ~140 nm and d<sub>H</sub> ~250 nm). The HNPs were examined further for their stability, degradation, MDM uptake, and drug delivery efficiency by studying the inhibiti"],"journal":["Pharmaceutics"],"pubmed_title":["PEG-Lipid-PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs."],"pmcid":["PMC10891717"],"funding_grant_id":["471397362","316213987","INST 275/315-1 FUGG"],"pubmed_authors":["Ismail J","Pretzel D","Rezaei K","Nischang I","Dahlke P","Czaplewska JA","Jordan PM","Schubert US","Beringer-Siemers B","Tsarenko E","Stumpf S","Vollrath A","Klepsch LC","Hoeppener S","Werz O"],"additional_accession":[]},"is_claimable":false,"name":"PEG-Lipid-PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs.","description":"Hybrid nanoparticles (HNPs) were designed by combining a PLGA core with a lipid shell that incorporated PEG-Lipid conjugates with various functionalities (-RGD, -cRGD, -NH<sub>2</sub>, and -COOH) to create targeted drug delivery systems. Loaded with a neutral lipid orange dye, the HNPs were extensively characterized using various techniques and investigated for their uptake in human monocyte-derived macrophages (MDMs) using FC and CLSM. Moreover, the best-performing HNPs (i.e., HNP-COOH and HNP-RGD as well as HNP-RGD/COOH mixed) were loaded with the anti-inflammatory drug BRP-201 and prepared in two size ranges (d<sub>H</sub> ~140 nm and d<sub>H</sub> ~250 nm). The HNPs were examined further for their stability, degradation, MDM uptake, and drug delivery efficiency by studying the inhibiti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-19T14:47:46.113Z","creation":"2025-04-19T14:47:46.113Z"},"accession":"S-EPMC10891717","cross_references":{"pubmed":["38399248"],"doi":["10.3390/pharmaceutics16020187"]}}