biostudies-literatureWen Yinnovation program of the Chinese academy of agricultural sciencesopen competition program of the top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong ProvinceGansu major science and technology projectsNational Key R&D Program of Chinadirector’s funding of Lanzhou Veterinary Research Institutetechnology major project of Gansu ProvinceDevelopment of African swine fever subunit vaccine from Lanzhou Veterinary Research Institute400https://www.ebi.ac.uk/biostudies/studies/S-EPMC10892147biostudies-literatureUnknown12(2)African swine fever (ASF) is an acute and severe disease transmitted among domestic pigs and wild boars. This disease is notorious for its high mortality rate and has caused great losses to the world's pig industry in the past few years. After infection, pigs can develop symptoms such as high fever, inflammation, and acute hemorrhage, finally leading to death. African swine fever virus (ASFV) is the causal agent of ASF; it is a large DNA virus with 150-200 genes. Elucidating the functions of each gene could provide insightful information for developing prevention and control methods. Herein, to investigate the function of I267L, porcine alveolar macrophages (PAMs) infected with an I267L-deleted ASFV strain (named ∆I267L) and wild-type ASFV for 18 h and 36 h were taken for transcriptome seqMicroorganismsAfrican Swine Fever Virus I267L Is a Hemorrhage-Related Gene Based on Transcriptome Analysis.PMC108921472023SDZG0221ZD3NA001-522ZD6NA0012021YFD18001002021YFD180130220ZD7NA00621ZD3NA001CAAS-ASTIP-JBGS-20210401CAAS-ASTIP-2021-LVRILVRI-SZJJ-202106Wen YZheng HGuan GZhang JLi DRen JRu YDuan XfalseAfrican Swine Fever Virus I267L Is a Hemorrhage-Related Gene Based on Transcriptome Analysis.African swine fever (ASF) is an acute and severe disease transmitted among domestic pigs and wild boars. This disease is notorious for its high mortality rate and has caused great losses to the world's pig industry in the past few years. After infection, pigs can develop symptoms such as high fever, inflammation, and acute hemorrhage, finally leading to death. African swine fever virus (ASFV) is the causal agent of ASF; it is a large DNA virus with 150-200 genes. Elucidating the functions of each gene could provide insightful information for developing prevention and control methods. Herein, to investigate the function of I267L, porcine alveolar macrophages (PAMs) infected with an I267L-deleted ASFV strain (named ∆I267L) and wild-type ASFV for 18 h and 36 h were taken for transcriptome seq2024-01-01T00:00:00Z2024 Feb2026-07-03T03:16:48.65Z2024-11-07T09:07:20.959ZS-EPMC108921473839980410.3390/microorganisms12020400