biostudies-literatureUnknown16(4)Weinstein S<h4>Background</h4>Obesity is associated with dyslipidemia, and weight loss can improve obese patients' lipid profile. Here, we assessed whether non-interventional weight changes are associated with alterations in lipid profile, particularly the triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C).<h4>Methods</h4>In this retrospective analysis of subjects referred to medical screening, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), TG, and HDL-C levels were measured annually. Patients were divided according to BMI changes between visits. The primary outcomes were the changes in LDL-C, TG, HDL-C, and the TG/HDL-C ratio between visits.<h4>Results</h4>The final analysis included 18,828 subjects. During the year of follow-up, 9.3% of the studyNutrients486https://www.ebi.ac.uk/biostudies/studies/S-EPMC10892159biostudies-literatureNon-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio.PMC10892159Kaplan ALeibowitz AShlomai GGrossman EHod TMaor EWeinstein SfalseNon-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio.<h4>Background</h4>Obesity is associated with dyslipidemia, and weight loss can improve obese patients' lipid profile. Here, we assessed whether non-interventional weight changes are associated with alterations in lipid profile, particularly the triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C).<h4>Methods</h4>In this retrospective analysis of subjects referred to medical screening, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), TG, and HDL-C levels were measured annually. Patients were divided according to BMI changes between visits. The primary outcomes were the changes in LDL-C, TG, HDL-C, and the TG/HDL-C ratio between visits.<h4>Results</h4>The final analysis included 18,828 subjects. During the year of follow-up, 9.3% of the study2024-01-01T00:00:00Z2024 Feb2025-04-19T14:47:04.98Z2025-04-19T14:47:04.98ZS-EPMC108921593839881110.3390/nu16040486