biostudies-literatureYudintceva NGovernment of India under Indo-Russia cooperation programministry of Education (MoE) Govt of India through the SPARCSaint-Petersburg State Research Institute of Phthisiopulmonology within the framework of the State task of the Ministry of Health of the Russian Federationministry of Education (MoE) Govt of India through the SPARC (Scheme for Promotion of Academic and Research Collaboration)Russian Federal Academic Leadership Program Priority 2030Technische Universität München (TUM) within the DFG funding programme Open Access Publishing.4495https://www.ebi.ac.uk/biostudies/studies/S-EPMC10894196biostudies-literatureUnknown14(1)Extrapulmonary tuberculosis with a renal involvement can be a manifestation of a disseminated infection that requires therapeutic intervention, particularly with a decrease in efficacy of conventional regimens. In the present study, we investigated the therapeutic potency of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in the complex anti-tuberculosis treatment (ATT). A rabbit model of renal tuberculosis (rTB) was constructed by injecting of the standard strain Mycobacterium tuberculosis H37Rv into the cortical layer of the kidney parenchyma. Isolated rabbit MSC-EVs were intravenously administered once as an addition to standard ATT (isoniazid, pyrazinamide, and ethambutol). The therapeutic efficacy was assessed by analyzing changes of blood biochemical biomarkers and levScientific reportsMesenchymal stem cells-derived extracellular vesicles for therapeutics of renal tuberculosis.PMC10894196N 121112600145-2)No SPARC/2019-2020/P2420/SLN 121112600145‐2)Project No. INT/RUS/RFBR/380Oganesyan EYablonskiy PMuraviov ASonawane AMikhailova NZiganshin RDyakova MVinogradova TEsmedlyaeva DRemezova AShevtsov MBobkov DMaslak OYudintceva NBehl ABlum NBogdanova ESonawane SHSulatsky MGarapach IShailja SinghKovalchuk SfalseMesenchymal stem cells-derived extracellular vesicles for therapeutics of renal tuberculosis.Extrapulmonary tuberculosis with a renal involvement can be a manifestation of a disseminated infection that requires therapeutic intervention, particularly with a decrease in efficacy of conventional regimens. In the present study, we investigated the therapeutic potency of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in the complex anti-tuberculosis treatment (ATT). A rabbit model of renal tuberculosis (rTB) was constructed by injecting of the standard strain Mycobacterium tuberculosis H37Rv into the cortical layer of the kidney parenchyma. Isolated rabbit MSC-EVs were intravenously administered once as an addition to standard ATT (isoniazid, pyrazinamide, and ethambutol). The therapeutic efficacy was assessed by analyzing changes of blood biochemical biomarkers and lev2024-01-01T00:00:00Z2024 Feb2025-04-22T13:18:26.951Z2025-04-06T00:38:37.638ZS-EPMC108941963840226010.1038/s41598-024-54992-z