{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(2)"],"submitter":["Harris AL"],"funding":["Bedford Research Foundation"],"pubmed_abstract":["<h4>Objective</h4>This study is to discover hormone pathways active in early cleaving human embryos.<h4>Methods</h4>A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency.<h4>Results</h4>Over half of the 152 hormones and receptors were silent on the arrays of all cell types, and more were detected at high or moderate levels on the 8-cell arrays than on the pluripotent cell or fibroblast arrays. Eight hormone family genes were uniquely detected at least 22-fold higher on the 8-cell arrays than the stem cell arrays: AVPI1, CCK, CORT, FSTL4, GIP, GPHA2, OXT, and PPY suggesting novel roles for these proteins in early development. Ox"],"journal":["Journal of assisted reproduction and genetics"],"pagination":["323-332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10894797"],"repository":["biostudies-literature"],"pubmed_title":["Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin."],"pmcid":["PMC10894797"],"pubmed_authors":["Kiessling AA","Harris AL","Dinopoulou V","Loutradis D","Drakakis P"],"additional_accession":[]},"is_claimable":false,"name":"Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin.","description":"<h4>Objective</h4>This study is to discover hormone pathways active in early cleaving human embryos.<h4>Methods</h4>A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency.<h4>Results</h4>Over half of the 152 hormones and receptors were silent on the arrays of all cell types, and more were detected at high or moderate levels on the 8-cell arrays than on the pluripotent cell or fibroblast arrays. Eight hormone family genes were uniquely detected at least 22-fold higher on the 8-cell arrays than the stem cell arrays: AVPI1, CCK, CORT, FSTL4, GIP, GPHA2, OXT, and PPY suggesting novel roles for these proteins in early development. Ox","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-05T10:19:15.932Z","creation":"2025-04-05T10:19:15.932Z"},"accession":"S-EPMC10894797","cross_references":{"pubmed":["38133877"],"doi":["10.1007/s10815-023-03002-8"]}}