{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Das Gupta K"],"funding":["DHAC | National Health and Medical Research Council","Rebecca L. Cooper Medical Research Foundation","DHAC | National Health and Medical Research Council (NHMRC)"],"pagination":["e2315190121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10895263"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(8)"],"pubmed_abstract":["Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion transporter required for epithelial homeostasis in the lung and other organs, with <i>CFTR</i> mutations leading to the autosomal recessive genetic disease CF. Apart from excessive mucus accumulation and dysregulated inflammation in the airways, people with CF (pwCF) exhibit defective innate immune responses and are susceptible to bacterial respiratory pathogens such as <i>Pseudomonas aeruginosa</i>. Here, we investigated the role of CFTR in macrophage antimicrobial responses, including the zinc toxicity response that is used by these innate immune cells against intracellular bacteria. Using both pharmacological approaches, as well as cells derived from pwCF, we show that CFTR is required for uptake and clearance of pat"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["CFTR is required for zinc-mediated antibacterial defense in human macrophages."],"pmcid":["PMC10895263"],"funding_grant_id":["021765","APP1193840","APP1194406"],"pubmed_authors":["Curson JEB","Schembri MA","Das Gupta K","Sweet MJ","Tarique AA","Fantino E","Kapetanovic R","Sly PD"],"additional_accession":[]},"is_claimable":false,"name":"CFTR is required for zinc-mediated antibacterial defense in human macrophages.","description":"Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion transporter required for epithelial homeostasis in the lung and other organs, with <i>CFTR</i> mutations leading to the autosomal recessive genetic disease CF. Apart from excessive mucus accumulation and dysregulated inflammation in the airways, people with CF (pwCF) exhibit defective innate immune responses and are susceptible to bacterial respiratory pathogens such as <i>Pseudomonas aeruginosa</i>. Here, we investigated the role of CFTR in macrophage antimicrobial responses, including the zinc toxicity response that is used by these innate immune cells against intracellular bacteria. Using both pharmacological approaches, as well as cells derived from pwCF, we show that CFTR is required for uptake and clearance of pat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-03T21:31:09.279Z","creation":"2025-04-03T21:31:09.279Z"},"accession":"S-EPMC10895263","cross_references":{"pubmed":["38363865"],"doi":["10.1073/pnas.2315190121"]}}