{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martino F"],"funding":["ANPCYT, Argentina","National Ministry of Health of Argentina","Public Health Ontario Laboratory"],"pagination":["e0294820"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10896549"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(2)"],"pubmed_abstract":["Mobile colistin resistance (mcr) genes were described recently in Gram-negative bacteria including carbapenem-resistant Enterobacterales. There are ten mcr genes described in different Gram-negative bacteria, however, Escherichia coli harboring mcr-1 gene is by far the most frequent combination. In Argentina, mcr-1 gene was characterized only on plasmids belonging to IncI2 group. The aim of this work was to get new insights of mcr-1-harboring plasmids from E. coli. Eight E. coli isolates from a larger collection of 192 clinical E. coli isolates carrying the mcr-1 gene were sequenced using next generation technologies. Three isolates belonged to ST131 high-risk clone, and five to single ST, ST38, ST46, ST226, ST224, and ST405. Eight diverse mcr-1-harboring plasmids were analyzed: IncI2 (1),"],"journal":["PloS one"],"pubmed_title":["New insights on mcr-1-harboring plasmids from human clinical Escherichia coli isolates."],"pmcid":["PMC10896549"],"funding_grant_id":["Préstamo BID-PICT-2021-I-A-0603","Regular Budget"],"pubmed_authors":["Martino F","Corso A","Melano R","Menocal MA","Petroni A","Faccone D"],"additional_accession":[]},"is_claimable":false,"name":"New insights on mcr-1-harboring plasmids from human clinical Escherichia coli isolates.","description":"Mobile colistin resistance (mcr) genes were described recently in Gram-negative bacteria including carbapenem-resistant Enterobacterales. There are ten mcr genes described in different Gram-negative bacteria, however, Escherichia coli harboring mcr-1 gene is by far the most frequent combination. In Argentina, mcr-1 gene was characterized only on plasmids belonging to IncI2 group. The aim of this work was to get new insights of mcr-1-harboring plasmids from E. coli. Eight E. coli isolates from a larger collection of 192 clinical E. coli isolates carrying the mcr-1 gene were sequenced using next generation technologies. Three isolates belonged to ST131 high-risk clone, and five to single ST, ST38, ST46, ST226, ST224, and ST405. Eight diverse mcr-1-harboring plasmids were analyzed: IncI2 (1),","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-05T03:19:58.722Z","creation":"2025-05-18T12:52:43.606Z"},"accession":"S-EPMC10896549","cross_references":{"pubmed":["38408071"],"doi":["10.1371/journal.pone.0294820"]}}