biostudies-literatureUnknown7(2)Ata F<h4>Introduction</h4>Insulin-like growth factor-2 (IGF-2)-mediated hypoglycemia is a rare yet clinically significant entity with considerable morbidity and mortality. Existing literature is limited and fails to offer a comprehensive understanding of its clinical trajectory, management and prognostication.<h4>Methods</h4>Systematic review of English-language articles reporting primary patient data on IMH was searched using electronic databases (PubMed, Scopus and Embase) from any date up to 21 December 2022. Data were analysed in STATA-16.<h4>Results</h4>The systematic review contains 172 studies, including 1 Randomised controlled trial, 1 prospective observational study, 5 retrospective observational studies, 150 case reports, 11 case series and 4 conference abstracts. A total of 233 patieEndocrinology, diabetes & metabolisme00471https://www.ebi.ac.uk/biostudies/studies/S-EPMC10897872biostudies-literatureA systematic review of literature on Insulin-like growth factor-2-mediated hypoglycaemia in non-islet cell tumours.PMC10897872Khamees IMalkawi LKhan AAAljaloudi EMohamed AAl-Sadi AAnumChoudry HAta FfalseA systematic review of literature on Insulin-like growth factor-2-mediated hypoglycaemia in non-islet cell tumours.<h4>Introduction</h4>Insulin-like growth factor-2 (IGF-2)-mediated hypoglycemia is a rare yet clinically significant entity with considerable morbidity and mortality. Existing literature is limited and fails to offer a comprehensive understanding of its clinical trajectory, management and prognostication.<h4>Methods</h4>Systematic review of English-language articles reporting primary patient data on IMH was searched using electronic databases (PubMed, Scopus and Embase) from any date up to 21 December 2022. Data were analysed in STATA-16.<h4>Results</h4>The systematic review contains 172 studies, including 1 Randomised controlled trial, 1 prospective observational study, 5 retrospective observational studies, 150 case reports, 11 case series and 4 conference abstracts. A total of 233 patie2024-01-01T00:00:00Z2024 Mar2025-05-29T20:27:12.571Z2024-11-07T01:00:48.566ZS-EPMC108978723841103910.1002/edm2.471