{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McAloney CA"],"funding":["Nationwide Children’s Director’s Strategic Development Fund","NIH CTSA","CancerFree KIDS Foundation","Sarcoma Foundation of America","NCATS NIH HHS","Steps for Sarcoma Foundation","Translational Studies Grant from the Osteosarcoma Institute","NIH/ORIP","NIH/NCI","NCI NIH HHS","NIH HHS","Hyundai Hope on Wheels Young Investigator Award"],"pagination":["259-282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10899530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(1)"],"pubmed_abstract":["Purpose
For patients with osteosarcoma, disease-related mortality most often results from lung metastasis-a phenomenon shared with many solid tumors. While established metastatic lesions behave aggressively, very few of the tumor cells that reach the lung will survive. By identifying mechanisms that facilitate survival of disseminated tumor cells, we can develop therapeutic strategies that prevent and treat metastasis.Methods
We analyzed single cell RNA-sequencing (scRNAseq) data from murine metastasis-bearing lungs to interrogate changes in both host and tumor cells during colonization. We used these data to elucidate pathways that become activated in cells that survive dissemination and identify candidate host-derived signals that drive activation. We validated these find"],"journal":["Cellular oncology (Dordrecht, Netherlands)"],"pubmed_title":["Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization."],"pmcid":["PMC10899530"],"funding_grant_id":["T32 CA009338","UL1TR002733","R01CA260178","T32CA009338","K01OD031811","T32CA269052","T32 CA269052","UL1 TR002733","R01 CA260178","K08 CA201638","K01 OD031811"],"pubmed_authors":["Cannon MV","Cam M","Budhathoki Y","Franz EM","Gross AC","McAloney CA","Duhen R","Makkawi R","Davies AE","Roberts RD","Vetter TA"],"additional_accession":[]},"is_claimable":false,"name":"Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.","description":"Purpose
For patients with osteosarcoma, disease-related mortality most often results from lung metastasis-a phenomenon shared with many solid tumors. While established metastatic lesions behave aggressively, very few of the tumor cells that reach the lung will survive. By identifying mechanisms that facilitate survival of disseminated tumor cells, we can develop therapeutic strategies that prevent and treat metastasis.Methods
We analyzed single cell RNA-sequencing (scRNAseq) data from murine metastasis-bearing lungs to interrogate changes in both host and tumor cells during colonization. We used these data to elucidate pathways that become activated in cells that survive dissemination and identify candidate host-derived signals that drive activation. We validated these find","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-15T09:25:46.49Z","creation":"2025-05-18T12:53:02.852Z"},"accession":"S-EPMC10899530","cross_references":{"pubmed":["37676378"],"doi":["10.1007/s13402-023-00867-w"]}}