biostudies-literatureUnknown15Wei SWheat dwarf virus (WDV) has caused considerable economic loss in the global production of grain crops. Knowledge of the evolutionary biology and population history of the pathogen remain poorly understood. We performed molecular evolution and worldwide phylodynamic analyses of the virus based on the genes in the protein-coding region of the entire viral genome. Our results showed that host-driven and geography-driven adaptation are major factors that affects the evolution of WDV. Bayesian phylogenetic analysis estimates that the average WDV substitution rate was 4.240 × 10^-4 substitutions/site/year (95% credibility interval, 2.828 × 10^-4-5.723 × 10^-4), and the evolutionary rates of genes encoding proteins with virion-sense transcripts and genes encoding proFrontiers in microbiology1314526https://www.ebi.ac.uk/biostudies/studies/S-EPMC10901289biostudies-literatureMolecular evolution and phylogeographic analysis of wheat dwarf virus.PMC10901289Yang HLuo PLiu LWei SChen GZhang MHuang LGong GfalseMolecular evolution and phylogeographic analysis of wheat dwarf virus.Wheat dwarf virus (WDV) has caused considerable economic loss in the global production of grain crops. Knowledge of the evolutionary biology and population history of the pathogen remain poorly understood. We performed molecular evolution and worldwide phylodynamic analyses of the virus based on the genes in the protein-coding region of the entire viral genome. Our results showed that host-driven and geography-driven adaptation are major factors that affects the evolution of WDV. Bayesian phylogenetic analysis estimates that the average WDV substitution rate was 4.240 × 10^-4 substitutions/site/year (95% credibility interval, 2.828 × 10^-4-5.723 × 10^-4), and the evolutionary rates of genes encoding proteins with virion-sense transcripts and genes encoding pro2024-01-01T00:00:00Z20242026-07-15T02:06:21.317Z2025-04-05T21:46:40.83ZS-EPMC109012893841964110.3389/fmicb.2024.1314526