{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(2)"],"submitter":["Ma W"],"pubmed_abstract":["<h4>Background</h4>Osteoarthritis (OA), a prevalent musculoskeletal disorder, has been suggested to have a potential association with metabolic syndrome, particularly lipid metabolism. Studies exploring the effects of lipid-lowering drugs on OA have yielded conflicting results.<h4>Objective</h4>This study employed a drug-targeted Mendelian randomization approach to investigate the association between genetically predicted lipid-modulating effects of commonly targeted lipid-lowering agents and the risk of OA, with the aim of providing a theoretical foundation for the use of lipid-lowering drugs in OA treatment.<h4>Methods</h4>Employing Mendelian randomization (MR) analysis, we examined the potential causal relationship between lipid-lowering drugs and OA. Genetic variants associated with LD"],"journal":["PloS one"],"pagination":["e0293960"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10901306"],"repository":["biostudies-literature"],"pubmed_title":["Association of lipid-lowering drugs with osteoarthritis outcomes from a drug-target Mendelian randomization study."],"pmcid":["PMC10901306"],"pubmed_authors":["Xiong Y","Zhang Z","Chen H","Ma W"],"additional_accession":[]},"is_claimable":false,"name":"Association of lipid-lowering drugs with osteoarthritis outcomes from a drug-target Mendelian randomization study.","description":"<h4>Background</h4>Osteoarthritis (OA), a prevalent musculoskeletal disorder, has been suggested to have a potential association with metabolic syndrome, particularly lipid metabolism. Studies exploring the effects of lipid-lowering drugs on OA have yielded conflicting results.<h4>Objective</h4>This study employed a drug-targeted Mendelian randomization approach to investigate the association between genetically predicted lipid-modulating effects of commonly targeted lipid-lowering agents and the risk of OA, with the aim of providing a theoretical foundation for the use of lipid-lowering drugs in OA treatment.<h4>Methods</h4>Employing Mendelian randomization (MR) analysis, we examined the potential causal relationship between lipid-lowering drugs and OA. Genetic variants associated with LD","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-15T02:05:32.01Z","creation":"2025-04-05T21:49:40.949Z"},"accession":"S-EPMC10901306","cross_references":{"pubmed":["38416763"],"doi":["10.1371/journal.pone.0293960"]}}