{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Borker PV"],"funding":["NCATS NIH HHS","NHLBI NIH HHS","Office of AIDS Research","National Institutes of Health","National Heart Lung and Blood Institute","Data Analysis and Coordination Center"],"pagination":["zpae001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10901437"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(1)"],"pubmed_abstract":["<h4>Study objectives</h4>Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV.<h4>Methods</h4>Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio.<h4>Results</h4>Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm<sup>3</sup> were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm<sup>3</sup> (<i>p</i> = 0.05) and a 5.6% (<i>p</i> = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm<sup>3</sup> (<i>p</i> = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (<i>p</i> = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations.<h4>Conclusions</h4>Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH."],"journal":["Sleep advances : a journal of the Sleep Research Society"],"pubmed_title":["Shorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV."],"pmcid":["PMC10901437"],"funding_grant_id":["UL1 TR003098","U01 HL157004","K12 HL143886","U01-HL146193","UL1 TR001881","U01 HL146204","HL143886","HL082610","UL1-TR001881","U01-HL146242","U01-HL146333","U01 HL146208","U01-HL146201","U01 HL146242","UL1-TR003098","K23 HL169022","U01 HL146240","U01 HL146333","U01 HL146201","U01 HL146193","T32 HL082610"],"pubmed_authors":["Punjabi NM","Borker PV","Margolick JB","Hyong-Jin Cho J","Rinaldo CR","Macatangay BJ","Patel SR","Stosor V","McKay H"],"additional_accession":[]},"is_claimable":false,"name":"Shorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.","description":"<h4>Study objectives</h4>Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV.<h4>Methods</h4>Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio.<h4>Results</h4>Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm<sup>3</sup> were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm<sup>3</sup> (<i>p</i> = 0.05) and a 5.6% (<i>p</i> = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm<sup>3</sup> (<i>p</i> = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (<i>p</i> = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations.<h4>Conclusions</h4>Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-26T03:24:47.31Z","creation":"2025-04-05T21:49:47.142Z"},"accession":"S-EPMC10901437","cross_references":{"pubmed":["38420256"],"doi":["10.1093/sleepadvances/zpae001"]}}