biostudies-literatureBorker PVNCATS NIH HHSNHLBI NIH HHSOffice of AIDS ResearchNational Institutes of HealthNational Heart Lung and Blood InstituteData Analysis and Coordination Centerzpae001https://www.ebi.ac.uk/biostudies/studies/S-EPMC10901437biostudies-literatureUnknown5(1)<h4>Study objectives</h4>Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV.<h4>Methods</h4>Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio.<h4>Results</h4>Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm³ were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm³ (<i>p</i> = 0.05) and a 5.6% (<i>p</i> = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm³ (<i>p</i> = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (<i>p</i> = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations.<h4>Conclusions</h4>Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.Sleep advances : a journal of the Sleep Research SocietyShorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.PMC10901437UL1 TR003098U01 HL157004K12 HL143886U01-HL146193UL1 TR001881U01 HL146204HL143886HL082610UL1-TR001881U01-HL146242U01-HL146333U01 HL146208U01-HL146201U01 HL146242UL1-TR003098K23 HL169022U01 HL146240U01 HL146333U01 HL146201U01 HL146193T32 HL082610Punjabi NMBorker PVMargolick JBHyong-Jin Cho JRinaldo CRMacatangay BJPatel SRStosor VMcKay HfalseShorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.<h4>Study objectives</h4>Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV.<h4>Methods</h4>Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio.<h4>Results</h4>Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm³ were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm³ (<i>p</i> = 0.05) and a 5.6% (<i>p</i> = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm³ (<i>p</i> = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (<i>p</i> = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations.<h4>Conclusions</h4>Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.2024-01-01T00:00:00Z20242026-06-26T03:24:47.31Z2025-04-05T21:49:47.142ZS-EPMC109014373842025610.1093/sleepadvances/zpae001