{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nesamari R"],"funding":["European & Developing Countries Clinical Trials Partnership (EDCTP)","NIAID NIH HHS","FIC NIH HHS","Wellcome Trust"],"pagination":["162-169.e3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10901529"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(2)"],"pubmed_abstract":["Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has given rise to recombinant Omicron lineages that dominate globally (XBB.1), as well as the emergence of hypermutated variants (BA.2.86). In this context, durable and cross-reactive T cell immune memory is critical for continued protection against severe COVID-19. We examined T cell responses to SARS-CoV-2 approximately 1.5 years since Omicron first emerged. We describe sustained CD4+ and CD8+ spike-specific T cell memory responses in healthcare workers in South Africa (n = 39) who were vaccinated and experienced at least one SARS-CoV-2 infection. Spike-specific T cells are highly cross-reactive with all Omicron variants tested, including BA.2.86. Abundant nucleocapsid and membrane-specific T cells are detectable in most participants. The bulk of SARS-CoV-2-specific T cell responses have an early-differentiated phenotype, explaining their persistent nature. Overall, hybrid immunity leads to the accumulation of spike and non-spike T cells evident 3.5 years after the start of the pandemic, with preserved recognition of highly mutated SARS-CoV-2 variants."],"journal":["Cell host & microbe"],"pubmed_title":["Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant."],"pmcid":["PMC10901529"],"funding_grant_id":["75N93021C00016","TMA2016SF-1535","D43 TW010559","203135/Z/16/Z","222754","75N93019C00065","TMA2017SF-1951","226137/Z/22/Z"],"pubmed_authors":["Keeton RS","Mosala P","Hoft MA","Baguma R","Sette A","Riou C","Omondi MA","Mennen M","Skelem S","Grifoni A","Adriaanse M","Ngomti A","Nesamari R","Besethi AS","Clark GM","Nkayi AA","Ntusi NAB","Magugu SFJ","Walters A","Burgers WA"],"additional_accession":[]},"is_claimable":false,"name":"Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant.","description":"Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has given rise to recombinant Omicron lineages that dominate globally (XBB.1), as well as the emergence of hypermutated variants (BA.2.86). In this context, durable and cross-reactive T cell immune memory is critical for continued protection against severe COVID-19. We examined T cell responses to SARS-CoV-2 approximately 1.5 years since Omicron first emerged. We describe sustained CD4+ and CD8+ spike-specific T cell memory responses in healthcare workers in South Africa (n = 39) who were vaccinated and experienced at least one SARS-CoV-2 infection. Spike-specific T cells are highly cross-reactive with all Omicron variants tested, including BA.2.86. Abundant nucleocapsid and membrane-specific T cells are detectable in most participants. The bulk of SARS-CoV-2-specific T cell responses have an early-differentiated phenotype, explaining their persistent nature. Overall, hybrid immunity leads to the accumulation of spike and non-spike T cells evident 3.5 years after the start of the pandemic, with preserved recognition of highly mutated SARS-CoV-2 variants.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-04-29T11:53:33.983Z","creation":"2024-10-15T17:32:41.314Z"},"accession":"S-EPMC10901529","cross_references":{"pubmed":["38211583"],"doi":["10.1016/j.chom.2023.12.003"]}}