biostudies-literatureDe Gasperi RBLRD VANIA NIH HHSRRD VA714-733https://www.ebi.ac.uk/biostudies/studies/S-EPMC10902502biostudies-literatureUnknown41(5-6)Many military veterans who experienced blast-related traumatic brain injuries in the conflicts in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast develop cognitive and PTSD-related behavioral traits that are present for more than 1 year after exposure. We previously reported that a group II metabotropic receptor (mGluR2/3) antagonist reversed blast-induced behavioral traits. In this report, we explored mGluR2/3 expression following blast exposure in male rats. Western blotting revealed that mGluR2 protein (but not mGluR3) was increased in all brain regions studied (anterior cortex, hippocampus, and amygdala) at 43 or 52 weeks after blastJournal of neurotraumaMetabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure.PMC10902502I01 RX002660I01 BX005882P30 AG066514I21 RX003459I01 RX003846Patterson JCook DGAbutarboush RHof PRMorrison CLPryor DElder GADe Gasperi RGama Sosa MALind RStatz JKZhu CWAhlers STKawoos UPerez GMPerez Garcia GfalseMetabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure.Many military veterans who experienced blast-related traumatic brain injuries in the conflicts in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast develop cognitive and PTSD-related behavioral traits that are present for more than 1 year after exposure. We previously reported that a group II metabotropic receptor (mGluR2/3) antagonist reversed blast-induced behavioral traits. In this report, we explored mGluR2/3 expression following blast exposure in male rats. Western blotting revealed that mGluR2 protein (but not mGluR3) was increased in all brain regions studied (anterior cortex, hippocampus, and amygdala) at 43 or 52 weeks after blast2024-01-01T00:00:00Z2024 Mar2025-04-04T00:48:59.816Z2025-04-04T00:48:59.816ZS-EPMC109025023791711710.1089/neu.2023.0252