{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng TJ"],"funding":["Ministry of Science and Technology, Taiwan","Taipei City Hospital, Taiwan","Tri·Service General Hospital and the National Defense Medical Center","Ministry of Education in Taiwan"],"pagination":["2249-2261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10903253"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["248(23)"],"pubmed_abstract":["Chemokines critically orchestrate the tumorigenesis, metastasis, and stemness features of cancer cells that lead to poor outcomes. High plasma levels of transforming growth factor-β1 (TGFβ1) correlate with poor prognostic features in advanced lung cancer patients, thus suggesting the importance of TGFβ1 in the lung tumor microenvironment. However, the role of chemokines in TGFβ1-induced tumor stemness features remains unclear. Here, we clarify the previously undocumented role of CXCL1 in TGFβ1-induced lung cancer stemness features. CXCL1 and its receptor CXCR2 were significantly upregulated in TGFβ1-induced lung cancer stem cells (CSCs). CXCL1 silencing (shCXCL1) suppressed stemness gene expression, tumorsphere formation, colony formation, drug resistance, and <i>in vivo</i> tumorigenicity"],"journal":["Experimental biology and medicine (Maywood, N.J.)"],"pubmed_title":["TGFβ1 induces CXCL1 to promote stemness features in lung cancer."],"pmcid":["PMC10903253"],"funding_grant_id":["111W31210","109-2320-B-010-038","110-2320-B-A49A-514-MY3","110CRC-T210"],"pubmed_authors":["Sun GH","Peng TJ","Wu YC","Sun KH","Tang SJ"],"additional_accession":[]},"is_claimable":false,"name":"TGFβ1 induces CXCL1 to promote stemness features in lung cancer.","description":"Chemokines critically orchestrate the tumorigenesis, metastasis, and stemness features of cancer cells that lead to poor outcomes. High plasma levels of transforming growth factor-β1 (TGFβ1) correlate with poor prognostic features in advanced lung cancer patients, thus suggesting the importance of TGFβ1 in the lung tumor microenvironment. However, the role of chemokines in TGFβ1-induced tumor stemness features remains unclear. Here, we clarify the previously undocumented role of CXCL1 in TGFβ1-induced lung cancer stemness features. CXCL1 and its receptor CXCR2 were significantly upregulated in TGFβ1-induced lung cancer stem cells (CSCs). CXCL1 silencing (shCXCL1) suppressed stemness gene expression, tumorsphere formation, colony formation, drug resistance, and <i>in vivo</i> tumorigenicity","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-04T20:07:48.649Z","creation":"2025-04-04T20:07:48.649Z"},"accession":"S-EPMC10903253","cross_references":{"pubmed":["38158808"],"doi":["10.1177/15353702231220662"]}}