{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang T"],"funding":["Peking University Start-up Grant","Novo Nordisk Foundation","National Institute of Diabetes and Digestive and Kidney Diseases","Sigrid Juséliuksen Säätiö","National Heart, Lung, and Blood Institute","European Community","NHLBI NIH HHS","Sixth Framework Programme","Finnish Diabetes Research Foundation","Stanford Clinical and Translational Science Award","Boston Obesity Nutrition Research Center","California Walnut Commission","EVO-fund of Kuopio University Hospital","Generalitat Valenciana","United States–Israel Binational Science Foundation","Nutrition Science Initiative","Academy of Finland","National Key R&amp;D Program of China","Instituto de Salud Carlos III","NIDDK NIH HHS","American Heart Association Scientist Development Award","Juho Vainio Foundation","NIGMS NIH HHS"],"pagination":["9897048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10904069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["<i>Objective</i>. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (<i>TCF7L2</i>). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of <i>TCF7L2</i> rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).<i>Methods</i>. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect enc"],"journal":["Health data science"],"pubmed_title":["Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide."],"pmcid":["PMC10904069"],"funding_grant_id":["R01 DK091718","R21 HL126024","R01 HL071981","HL126024","5168","R01 DK091831","DK46200","R01 DK100383","1R01DK091831","QLK1-CT-2000-00618","P30 DK046200","1K12GM088033","HL071981","2011036","HL034594","T32 HL007034","129330","5254","PROMETEO-17/2017","BMU2018YJ002","R01 DK078616","T32HL007034","FP6-2005-513946","R01 HL034594","0730094N","UM1 DK078616","128315","K12 GM088033","283454","2020YFC2003401","5106","DK091718","U01 DK078616","DK078616","DK100383"],"pubmed_authors":["Cofan M","Qi L","Astrup A","Rajaram S","Gardner CD","Stancacova A","Martinez JA","Sabate J","Ma W","Sun D","Wang W","Oppert JM","Arner P","Uusitupa M","Hager J","Pedersen O","Heianza Y","Corella D","Del Gobbo LC","Hul G","de Mello VD","Ros E","Salas-Salvado J","Zhuang Z","Langin D","Hansen T","Sorensen TIA","Huang T","Fang Z","Saris WHM","Gao M","Svendstrup M","Tuomilehto J","Martinez-Gonzalez MA","Polak J","Laakso M","Lindstrom J"],"additional_accession":[]},"is_claimable":false,"name":"Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.","description":"<i>Objective</i>. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (<i>TCF7L2</i>). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of <i>TCF7L2</i> rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).<i>Methods</i>. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect enc","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-07-15T13:55:46.916Z","creation":"2026-07-05T03:12:08.691Z"},"accession":"S-EPMC10904069","cross_references":{"pubmed":["38487510"],"doi":["10.34133/2021/9897048"]}}