biostudies-literatureHuang TPeking University Start-up GrantNovo Nordisk FoundationNational Institute of Diabetes and Digestive and Kidney DiseasesSigrid Juséliuksen SäätiöNational Heart, Lung, and Blood InstituteEuropean CommunityNHLBI NIH HHSSixth Framework ProgrammeFinnish Diabetes Research FoundationStanford Clinical and Translational Science AwardBoston Obesity Nutrition Research CenterCalifornia Walnut CommissionEVO-fund of Kuopio University HospitalGeneralitat ValencianaUnited States–Israel Binational Science FoundationNutrition Science InitiativeAcademy of FinlandNational Key R&amp;D Program of ChinaInstituto de Salud Carlos IIINIDDK NIH HHSAmerican Heart Association Scientist Development AwardJuho Vainio FoundationNIGMS NIH HHS9897048https://www.ebi.ac.uk/biostudies/studies/S-EPMC10904069biostudies-literatureUnknown2021<i>Objective</i>. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (<i>TCF7L2</i>). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of <i>TCF7L2</i> rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).<i>Methods</i>. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encHealth data scienceInteraction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.PMC10904069R01 DK091718R21 HL126024R01 HL071981HL1260245168R01 DK091831DK46200R01 DK1003831R01DK091831QLK1-CT-2000-00618P30 DK0462001K12GM088033HL0719812011036HL034594T32 HL0070341293305254PROMETEO-17/2017BMU2018YJ002R01 DK078616T32HL007034FP6-2005-513946R01 HL0345940730094NUM1 DK078616128315K12 GM0880332834542020YFC20034015106DK091718U01 DK078616DK078616DK100383Cofan MQi LAstrup ARajaram SGardner CDStancacova AMartinez JASabate JMa WSun DWang WOppert JMArner PUusitupa MHager JPedersen OHeianza YCorella DDel Gobbo LCHul Gde Mello VDRos ESalas-Salvado JZhuang ZLangin DHansen TSorensen TIAHuang TFang ZSaris WHMGao MSvendstrup MTuomilehto JMartinez-Gonzalez MAPolak JLaakso MLindstrom JfalseInteraction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.<i>Objective</i>. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (<i>TCF7L2</i>). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of <i>TCF7L2</i> rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).<i>Methods</i>. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect enc2021-01-01T00:00:00Z20212026-07-15T13:55:46.916Z2026-07-05T03:12:08.691ZS-EPMC109040693848751010.34133/2021/9897048