{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu R"],"funding":["British Heart Foundation","Barts Charity","Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["e189-e198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10904120"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(740)"],"pubmed_abstract":["<h4>Background</h4>UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist.<h4>Aim</h4>To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK.<h4>Design and setting</h4>A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys.<h4>Method</h4>A CVD microsimulation model was developed using risk equations for myocardial infarction, stroke, coronary revascularisation, cancer, and vascular and non-vascular death, estimated using trial data. The authors calibrated and further developed"],"journal":["The British journal of general practice : the journal of the Royal College of General Practitioners"],"pubmed_title":["Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model."],"pmcid":["PMC10904120"],"funding_grant_id":["17/140/02","MGU0421","MR/R024227/1","CH/1996001/9454","NIHR203330"],"pubmed_authors":["Robson J","Neil A","Glynn R","Landray M","Zannad F","Haynes R","Lonn E","Serruys PW","Wilson K","Clearfield M","Mihaylova B","Wedel H","Williams C","Wanner C","Nicolis EB","Blauw GJ","Varigos J","MacFadyen J","Arashi H","Sacks F","Pedersen TR","Holdaas H","Blackwell L","Reith C","Smeeth L","Tonkin A","Downs JR","Kean S","Hawkins CM","Yamamguchi J","Knopp RH","Cobbe S","Tognoni G","Young R","Davies K","Welch KM","Braunwald E","Tavazzi L","Moye L","White H","Betteridge DJ","Blazing M","Lucci D","Sever P","Sattar N","Knatterud G","Shepherd J","Koren M","Marchioli R","Baigent C","Shaw J","Zhou J","Krane V","Ridker PM","Holland L","Probstfield JL","Maggioni A","Kastelein JJ","Sleight P","Parish S","Hovingh GK","Goldbourt U","Gray A","Kirby A","Keech A","Cannon CP","Simpson L","Fulcher J","Ford I","Pressel S","Durrington PN","Bowman L","Armitage J","Yusuf S","Clarke R","Halls H","Fellstrom B","Goto S","Simes J","Gupta A","Herrington WG","Gotto A","Wikstrand J","Jardine A","Wu R","Barter P","Davis B","Colhoun HM","O'Connell R","Wiviott S","Hopewell J","Rahman M","Schwartz GG","Dahlof B","Amarenco P","Sabatine MS","Schlackow I","MacMahon S","Tobert J","Bosch J","Barnes E","Kitas G","Poulter N","Roberston M","Flather M","Franzosi MG","Peto R","Macfarlane P","Grimm R","Newman C","Marschner I","Furberg C","Kjekshus J","Emberson J","Murphy S","Schmieder R","Wilhelmsen L","Pfeffer M","CTT Collaboration secretariat CTT Collaboration trialists: A to Z trial (phase Z) AFCAPS/TEXCAPS (AirForce/Texas Coronary Atherosclerosis Prevention Study)ALERT (Assessment of Lescol in Renal Transplantation)ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)ALLIANCE (Aggressive Lipid-Lowering Initiation Abates New Cardiac Events)ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial)ASPEN (Atorvastatin Study for the Prevention of Coronary Heart Disease Endpoints in Non-Insulin Dependent Diabetes Mellitus)AURORA (A study to evaluate the Use of Rosuvastatin in subjects On Regular haemodialysis: an Assessment of survival and cardiovascular events)CARDS (Collaborative Atorvastatin Diabetes Study)CARE (Cholesterol And Recurrent Events Study)CORONA (Controlled Rosuvas","Hitman GA","Lemos J","Koenig W","Collins R","Bulbulia R","Preiss D","Latini R","Gordon D","Weis S","Packard C","Fuller J","Trompet S","LaRosa J"],"additional_accession":[]},"is_claimable":false,"name":"Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model.","description":"<h4>Background</h4>UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist.<h4>Aim</h4>To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK.<h4>Design and setting</h4>A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys.<h4>Method</h4>A CVD microsimulation model was developed using risk equations for myocardial infarction, stroke, coronary revascularisation, cancer, and vascular and non-vascular death, estimated using trial data. The authors calibrated and further developed","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T00:47:00.084Z","creation":"2026-06-27T03:04:49.122Z"},"accession":"S-EPMC10904120","cross_references":{"pubmed":["38373851"],"doi":["10.3399/BJGP.2023.0198"]}}