{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Y"],"funding":["Shanghai Municipal Health Commission","Science and Technology Commission of Shanghai Municipality","Shanghai Shenkang Hospital Development Center","National Natural Science Foundation of China","Shaanxi Administration of Traditional Chinese Medicine"],"pagination":["109258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10905006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(3)"],"pubmed_abstract":["Brain metastases (BM) of lung adenocarcinoma (LUAD) are the most common intracranial malignancy leading to death. However, the cellular origins and drivers of BM from LUAD have not been clarified. Cellular composition was characterized by single-cell sequencing analysis of primary lung adenocarcinoma (pLUAD), BM and lymph node metastasis (LNM) samples in GSE131907. Our study briefly analyzed the tumor microenvironment (TME), focusing on the role of epithelial cells (ECs) in BM. We have discovered a population of brain metastasis-associated epithelial cells (BMAECs) expressing SPP1, SAA1, and CDKN2A, and it has been observed that this population is mainly composed of aneuploid cells from pLUAD, playing a crucial role in brain metastasis. Our study concluded that both LNM and BM in LUAD originated from pLUAD lesions, but there is currently insufficient evidence to prove a direct association between BM lesions and LNM lesions, which provides inspiration for further investigation of the TME in BM."],"journal":["iScience"],"pubmed_title":["Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma."],"pmcid":["PMC10905006"],"funding_grant_id":["2021-2023)-0302","ZY-FWTX-7001","82304968","82004115","SHDC12018X20","18401901500"],"pubmed_authors":["Li X","Cao Y","Gu Z","Luo S","Song X","Fan R","Wu Y","Yang F","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma.","description":"Brain metastases (BM) of lung adenocarcinoma (LUAD) are the most common intracranial malignancy leading to death. However, the cellular origins and drivers of BM from LUAD have not been clarified. Cellular composition was characterized by single-cell sequencing analysis of primary lung adenocarcinoma (pLUAD), BM and lymph node metastasis (LNM) samples in GSE131907. Our study briefly analyzed the tumor microenvironment (TME), focusing on the role of epithelial cells (ECs) in BM. We have discovered a population of brain metastasis-associated epithelial cells (BMAECs) expressing SPP1, SAA1, and CDKN2A, and it has been observed that this population is mainly composed of aneuploid cells from pLUAD, playing a crucial role in brain metastasis. Our study concluded that both LNM and BM in LUAD originated from pLUAD lesions, but there is currently insufficient evidence to prove a direct association between BM lesions and LNM lesions, which provides inspiration for further investigation of the TME in BM.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-01T03:25:09.285Z","creation":"2025-04-06T17:14:58.481Z"},"accession":"S-EPMC10905006","cross_references":{"pubmed":["38433899"],"doi":["10.1016/j.isci.2024.109258"]}}