{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manandhar P"],"funding":["HHS | NIH | National Cancer Institute","NIAID NIH HHS","HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","NCI NIH HHS"],"pagination":["466-474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10906969"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["212(3)"],"pubmed_abstract":["Tim-3 is a transmembrane protein that is best known for being highly expressed on terminally exhausted CD8+ T cells associated with chronic infection and tumors, although its expression is not limited to those settings. Tim-3 is also expressed by CD8+ T cells during acute infection and by multiple other immune cell types, including CD4+ Th1 and regulatory T cells, dendritic cells, and mast cells. In this study, we investigated the role of Tim-3 signaling on CD8+ T cell memory using a Tim-3 conditional knockout mouse model and mice lacking the signaling portion of the Tim-3 cytoplasmic domain. Together, our results indicate that Tim-3 has at most a modest effect on the formation and function of CD8+ memory T cells."],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus."],"pmcid":["PMC10906969"],"funding_grant_id":["T32 CA082084","R01 AI138504","R01 CA206517","R03 AI131049"],"pubmed_authors":["Kane LP","Szymczak-Workman AL","Manandhar P"],"additional_accession":[]},"is_claimable":false,"name":"Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus.","description":"Tim-3 is a transmembrane protein that is best known for being highly expressed on terminally exhausted CD8+ T cells associated with chronic infection and tumors, although its expression is not limited to those settings. Tim-3 is also expressed by CD8+ T cells during acute infection and by multiple other immune cell types, including CD4+ Th1 and regulatory T cells, dendritic cells, and mast cells. In this study, we investigated the role of Tim-3 signaling on CD8+ T cell memory using a Tim-3 conditional knockout mouse model and mice lacking the signaling portion of the Tim-3 cytoplasmic domain. Together, our results indicate that Tim-3 has at most a modest effect on the formation and function of CD8+ memory T cells.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-05T10:18:54.128Z","creation":"2025-04-05T10:18:54.128Z"},"accession":"S-EPMC10906969","cross_references":{"pubmed":["38108417"],"doi":["10.4049/jimmunol.2300401"]}}