{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harewood R"],"funding":["Bundesministerium für Bildung und Forschung","Cancer Research UK","Mutuelle Générale de l&amp;apos;Education Nationale","NIHR Imperial Biomedical Research Centre","Centre International de Recherche sur le Cancer","European Commission","Generalitat de Catalunya","Deutsches Krebsforschungszentrum","Associazione Italiana per la Ricerca sul Cancro","Institut Gustave-Roussy","Instituto de Salud Carlos III","Rijksinstituut voor Volksgezondheid en Milieu","Ligue Contre le Cancer","University of Maryland School of Public Health","World Health Organization","Consejería de Salud y Familias, Junta de Andalucía","Kræftens Bekæmpelse","Deutsche Krebshilfe","Institut National de la Santé et de la Recherche Médicale","Ministerie van Volksgezondheid, Welzijn en Sport","Imperial College London","National Research Council","World Cancer Research Fund","Medical Research Council","Seventh Framework Programme","NCI NIH HHS","Department of Epidemiology and Biostatistics, University of California, San Francisco"],"pagination":["105024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10907191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["101"],"pubmed_abstract":["<h4>Background</h4>Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain.<h4>Methods</h4>In a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk.<h4>Findings</h4>Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (OR<sub>per doubling</sub> 0.60, 95% CI 0.47-0.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (OR<sub>per doubling</sub> 0.71, 95% CI 0.59-0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer.<h4>Interpretation</h4>Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations.<h4>Funding</h4>World Cancer Research Fund (reference: 2013/1002); European Commission (FP7: BBMRI-LPC; reference: 313010)."],"journal":["EBioMedicine"],"pubmed_title":["Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)."],"pmcid":["PMC10907191"],"funding_grant_id":["001","MR/M012190/1","PRCRPG-NOV22/100001","25004","U01 CA272529","313010","2013/1002","C8221/A29017"],"pubmed_authors":["Rothwell JA","Rinaldi S","Cross AJ","Viallon V","Sacerdote C","Kaaks R","Severi G","Tjonneland A","Castilla J","Chajes V","Schulze MB","Playdon M","Papier K","Murphy N","Keski-Rahkonen P","Besevic J","Chirlaque MD","Prehn C","Schmidt JA","Gicquiau A","Jakszyn PG","Gunter MJ","Katzke V","Masala G","Atxega AA","Wedekind R","Sanchez MJ","Prada M","Panico S","van Guelpen B","Jacobs I","Heath AK","Adamski J","Agnoli C","Summers SA","Harewood R","Achaintre D","Olsen A","Tong TYN"],"additional_accession":[]},"is_claimable":false,"name":"Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC).","description":"<h4>Background</h4>Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain.<h4>Methods</h4>In a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk.<h4>Findings</h4>Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (OR<sub>per doubling</sub> 0.60, 95% CI 0.47-0.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (OR<sub>per doubling</sub> 0.71, 95% CI 0.59-0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer.<h4>Interpretation</h4>Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations.<h4>Funding</h4>World Cancer Research Fund (reference: 2013/1002); European Commission (FP7: BBMRI-LPC; reference: 313010).","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-11T06:13:52.674Z","creation":"2025-04-07T01:06:27.98Z"},"accession":"S-EPMC10907191","cross_references":{"pubmed":["38412638"],"doi":["10.1016/j.ebiom.2024.105024"]}}