{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["50(2)"],"submitter":["Robba C"],"funding":["Università degli Studi di Genova"],"pubmed_abstract":["<h4>Purpose</h4>The use of arterial partial pressure of carbon dioxide (PaCO<sub>2</sub>) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO<sub>2</sub> in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO<sub>2</sub> values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO<sub>2</sub> with in-hospital mortality.<h4>Methods</h4>We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO<sub>2</sub"],"journal":["Intensive care medicine"],"pagination":["234-246"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10907416"],"repository":["biostudies-literature"],"pubmed_title":["Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study."],"pmcid":["PMC10907416"],"pubmed_authors":["Yahya HB","Deewan Y","Robert-Edan V","Baronial A","Matsuda T","Pineda AAV","Garcia-Ramos JC","Samir J","Ahmed H","ENIO collaborators","Monleon B","Azab MA","Abdelaty M","Alampi D","Papadas C","Codorniu A","Tringali E","Biston P","Orquera J","Castillo VHN","Battaglini D","Bicciato G","Mijangos JC","Launey Y","Brochet B","Hossain MM","Maugeri JG","Mishra SB","Chantziara V","Dominguez RCL","Jain G","Kaye C","Serrano A","Akkari A","Bellissima A","Oto J","Rodie-Talbere PA","Masseret E","Cinotti R","Citerio G","Bellini MM","Saxena S","Filipovic M","Companion B","Daniela PM","Khaled A","Gasca GA","Hourmant Y","Lazzeri N","Lamot L","Zarka J","Asehnoune K","Yadav G","Ippolito M","Gerretsen BM","Soyer B","Geslain M","Agrawal A","Georges D","Digitale JC","de la Torre Peredo N","Ghulam M","McCredie V","Reza ST","Robba C","Taccone FS","Cerda RC","Trujillo RM","Samal S","Agarwal S","Enomoto N","Piagnerelli M","Astuto M","Lopez-Morales M","Geeraerts T","Jha AK","Mouclier N","van Vliet P","Sklavou C","Schultz MJ","Azzam AY","Abback PS","Elbuzidi AAS","Gard SRI","Biais M","Miranda-Ackerman RC","Elhadi M","Arellano A","Ueno Y","Garcon P","Galicia-Espinosa F","Godoy DA","Cortegiani A","Welbourne J","Grillot N","Legros V","van Steenkiste J","van Meenen DMP","Huet O","Gergaud S","Ioakeimidou A","Gaugain S","Al-Gharyani MF","Suei EAA","Haenggi M","Sarrio E","Filippini M","Haedo MMG","Hashim A","Vetrugno L","Pirracchio R","Pietsch U","Vermeijden WJ","Masui N","Coombs AE","Badenes R","Fong N","Abbas A","Panda S","Rocco PR","Sala VL","Prol-Silva E","Alvarez P","Gurjar M","Brandi G","Andrea CN","Astier L","Zimmerli A","Cornet AD","van der Jagt M","Chavez MJR","Porter J","Rocco M","Perez-Torres D","Ortiz-Macias IX","Deana C","Lasocki S","Stevens RD","Chabanne R","Barbosa-Camacho FJ"],"additional_accession":[]},"is_claimable":false,"name":"Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.","description":"<h4>Purpose</h4>The use of arterial partial pressure of carbon dioxide (PaCO<sub>2</sub>) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO<sub>2</sub> in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO<sub>2</sub> values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO<sub>2</sub> with in-hospital mortality.<h4>Methods</h4>We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO<sub>2</sub","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-14T21:19:48.659Z","creation":"2025-04-04T20:41:12.444Z"},"accession":"S-EPMC10907416","cross_references":{"pubmed":["38294526"],"doi":["10.1007/s00134-023-07305-3"]}}