biostudies-literatureUnknown50(2)Robba CUniversità degli Studi di Genova<h4>Purpose</h4>The use of arterial partial pressure of carbon dioxide (PaCO₂) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO₂ in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO₂ values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO₂ with in-hospital mortality.<h4>Methods</h4>We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO<sub>2</subIntensive care medicine234-246https://www.ebi.ac.uk/biostudies/studies/S-EPMC10907416biostudies-literatureClinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.PMC10907416Yahya HBDeewan YRobert-Edan VBaronial AMatsuda TPineda AAVGarcia-Ramos JCSamir JAhmed HENIO collaboratorsMonleon BAzab MAAbdelaty MAlampi DPapadas CCodorniu ATringali EBiston POrquera JCastillo VHNBattaglini DBicciato GMijangos JCLauney YBrochet BHossain MMMaugeri JGMishra SBChantziara VDominguez RCLJain GKaye CSerrano AAkkari ABellissima AOto JRodie-Talbere PAMasseret ECinotti RCiterio GBellini MMSaxena SFilipovic MCompanion BDaniela PMKhaled AGasca GAHourmant YLazzeri NLamot LZarka JAsehnoune KYadav GIppolito MGerretsen BMSoyer BGeslain MAgrawal AGeorges DDigitale JCde la Torre Peredo NGhulam MMcCredie VReza STRobba CTaccone FSCerda RCTrujillo RMSamal SAgarwal SEnomoto NPiagnerelli MAstuto MLopez-Morales MGeeraerts TJha AKMouclier Nvan Vliet PSklavou CSchultz MJAzzam AYAbback PSElbuzidi AASGard SRIBiais MMiranda-Ackerman RCElhadi MArellano AUeno YGarcon PGalicia-Espinosa FGodoy DACortegiani AWelbourne JGrillot NLegros Vvan Steenkiste Jvan Meenen DMPHuet OGergaud SIoakeimidou AGaugain SAl-Gharyani MFSuei EAAHaenggi MSarrio EFilippini MHaedo MMGHashim AVetrugno LPirracchio RPietsch UVermeijden WJMasui NCoombs AEBadenes RFong NAbbas APanda SRocco PRSala VLProl-Silva EAlvarez PGurjar MBrandi GAndrea CNAstier LZimmerli ACornet ADvan der Jagt MChavez MJRPorter JRocco MPerez-Torres DOrtiz-Macias IXDeana CLasocki SStevens RDChabanne RBarbosa-Camacho FJfalseClinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.<h4>Purpose</h4>The use of arterial partial pressure of carbon dioxide (PaCO₂) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO₂ in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO₂ values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO₂ with in-hospital mortality.<h4>Methods</h4>We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO<sub>2</sub2024-01-01T00:00:00Z2024 Feb2026-07-14T21:19:48.659Z2025-04-04T20:41:12.444ZS-EPMC109074163829452610.1007/s00134-023-07305-3