{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thirion A"],"funding":["Poliomyelitis Research Foundation","North-West University","National Research Foundation"],"pagination":["33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10907482"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(2)"],"pubmed_abstract":["<h4>Introduction</h4> Because cerebrospinal fluid (CSF) samples are difficult to obtain for paediatric HIV, few studies have attempted to profile neurometabolic dysregulation.<h4>Aim and objective</h4>The aim of this exploratory study was to profile the neurometabolic state of CSF from a South African paediatric cohort using GCxGC-TOF/MS. The study included 54 paediatric cases (< 12 years), 42 HIV-negative controls and 12 HIV-positive individuals.<h4>Results</h4>The results revealed distinct metabolic alterations in the HIV-infected cohort. In the PLS-DA model, 18 metabolites significantly discriminated between HIV-infected and control groups. In addition, fold-change analysis, Mann-Whitney U tests, and effect size measurements verified these findings. Notably, lactose, myo-inositol, and g"],"journal":["Metabolomics : Official journal of the Metabolomic Society"],"pubmed_title":["An exploratory investigation of the CSF metabolic profile of HIV in a South African paediatric cohort using GCxGC-TOF/MS."],"pmcid":["PMC10907482"],"funding_grant_id":["23-96","TTK22031652","23/84"],"pubmed_authors":["Solomons R","Williams ME","Loots DT","Thirion A","Mason S"],"additional_accession":[]},"is_claimable":false,"name":"An exploratory investigation of the CSF metabolic profile of HIV in a South African paediatric cohort using GCxGC-TOF/MS.","description":"<h4>Introduction</h4> Because cerebrospinal fluid (CSF) samples are difficult to obtain for paediatric HIV, few studies have attempted to profile neurometabolic dysregulation.<h4>Aim and objective</h4>The aim of this exploratory study was to profile the neurometabolic state of CSF from a South African paediatric cohort using GCxGC-TOF/MS. The study included 54 paediatric cases (< 12 years), 42 HIV-negative controls and 12 HIV-positive individuals.<h4>Results</h4>The results revealed distinct metabolic alterations in the HIV-infected cohort. In the PLS-DA model, 18 metabolites significantly discriminated between HIV-infected and control groups. In addition, fold-change analysis, Mann-Whitney U tests, and effect size measurements verified these findings. Notably, lactose, myo-inositol, and g","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-06T23:34:56.541Z","creation":"2024-10-19T06:33:45.091Z"},"accession":"S-EPMC10907482","cross_references":{"pubmed":["38427142"],"doi":["10.1007/s11306-024-02098-y"]}}