biostudies-literatureUnknown10(5)Xiao LNatural Science Foundation of Guangdong Province<h4>Backgrounds</h4>Global fertility rates continue to decline and sperm quality is a prime factor affecting male fertility. Both extreme cold and heat have been demonstrated to be associated with decreased sperm quality, but no epidemiological studies have considered human adaptation to long-term temperature. Our aim was to conduct a multi-center retrospective cohort study to investigate exposure-response relationship between temperature anomaly (TA) that deviate from long-term climate patterns and sperm quality.<h4>Methods</h4>A total of 78,952 semen samples measured in 33,234 donors from 6 provincial human sperm banks in China were collected. This study considered heat and cold acclimatization to prolonged exposure in humans and explored the exposure-response relationship between TAs anHeliyone26765https://www.ebi.ac.uk/biostudies/studies/S-EPMC10907732biostudies-literatureEffects of temperature anomaly on sperm quality: A multi-center study of 33,234 men.PMC10907732Meng TZeng QNi HLi FSong CDai TGuo PWang LSheng HLi YXiao LWang QZhang XXu TCai XYu XfalseEffects of temperature anomaly on sperm quality: A multi-center study of 33,234 men.<h4>Backgrounds</h4>Global fertility rates continue to decline and sperm quality is a prime factor affecting male fertility. Both extreme cold and heat have been demonstrated to be associated with decreased sperm quality, but no epidemiological studies have considered human adaptation to long-term temperature. Our aim was to conduct a multi-center retrospective cohort study to investigate exposure-response relationship between temperature anomaly (TA) that deviate from long-term climate patterns and sperm quality.<h4>Methods</h4>A total of 78,952 semen samples measured in 33,234 donors from 6 provincial human sperm banks in China were collected. This study considered heat and cold acclimatization to prolonged exposure in humans and explored the exposure-response relationship between TAs an2024-01-01T00:00:00Z2024 Mar2026-06-12T05:48:38.977Z2025-04-05T11:38:52.326ZS-EPMC109077323843442010.1016/j.heliyon.2024.e26765