{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Dedeilia A"],"funding":["Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","Harvard Medical School","Harvard Catalyst","Huiying Foundation"],"pubmed_abstract":["<h4>Background</h4>In the current era of effective adjuvant therapies and de-escalation of surgery, distinguishing which patients with high-risk stage II melanoma are at increased risk of recurrence after excision of the primary lesion is essential to determining appropriate treatment and surveillance plans.<h4>Methods</h4>A single-center retrospective study analyzed patients with stage IIB or IIC melanoma. Demographic and tumor data were collected, and genomic analysis of formalin-fixed, paraffin-embedded tissue samples was performed via an internal next-generation sequencing (NGS) platform (SNaPshot). The end points examined were relapse-free survival (RFS), distant metastasis-free survival (DMFS), overall survival (OS), and melanoma-specific survival (MSS). Uni- and multivariable Cox re"],"journal":["Annals of surgical oncology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10908640"],"repository":["biostudies-literature"],"pubmed_title":["Factors Affecting Recurrence and Survival for Patients with High-Risk Stage II Melanoma."],"pmcid":["PMC10908640"],"funding_grant_id":["George","National Institutes of Health Award KL2 TR002542","Patricia K. Donahoe Award","Marie Vergottis Postdoctoral Fellowship"],"pubmed_authors":["Dedeilia A","Li S","Boland GM","Lawless A","Tunsiricharoengul S","Lwin T","Sharova T","Tarantino G","Liu D","Cohen S"],"additional_accession":[]},"is_claimable":false,"name":"Factors Affecting Recurrence and Survival for Patients with High-Risk Stage II Melanoma.","description":"<h4>Background</h4>In the current era of effective adjuvant therapies and de-escalation of surgery, distinguishing which patients with high-risk stage II melanoma are at increased risk of recurrence after excision of the primary lesion is essential to determining appropriate treatment and surveillance plans.<h4>Methods</h4>A single-center retrospective study analyzed patients with stage IIB or IIC melanoma. Demographic and tumor data were collected, and genomic analysis of formalin-fixed, paraffin-embedded tissue samples was performed via an internal next-generation sequencing (NGS) platform (SNaPshot). The end points examined were relapse-free survival (RFS), distant metastasis-free survival (DMFS), overall survival (OS), and melanoma-specific survival (MSS). Uni- and multivariable Cox re","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-18T14:47:58.854Z","creation":"2025-04-07T01:06:27.252Z"},"accession":"S-EPMC10908640","cross_references":{"pubmed":["38158497"],"doi":["10.1245/s10434-023-14724-5"]}}