biostudies-literatureUnknownDedeilia ADr. Miriam and Sheldon G. Adelson Medical Research FoundationHarvard Medical SchoolHarvard CatalystHuiying Foundation<h4>Background</h4>In the current era of effective adjuvant therapies and de-escalation of surgery, distinguishing which patients with high-risk stage II melanoma are at increased risk of recurrence after excision of the primary lesion is essential to determining appropriate treatment and surveillance plans.<h4>Methods</h4>A single-center retrospective study analyzed patients with stage IIB or IIC melanoma. Demographic and tumor data were collected, and genomic analysis of formalin-fixed, paraffin-embedded tissue samples was performed via an internal next-generation sequencing (NGS) platform (SNaPshot). The end points examined were relapse-free survival (RFS), distant metastasis-free survival (DMFS), overall survival (OS), and melanoma-specific survival (MSS). Uni- and multivariable Cox reAnnals of surgical oncologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10908640biostudies-literatureFactors Affecting Recurrence and Survival for Patients with High-Risk Stage II Melanoma.PMC10908640GeorgeNational Institutes of Health Award KL2 TR002542Patricia K. Donahoe AwardMarie Vergottis Postdoctoral FellowshipDedeilia ALi SBoland GMLawless ATunsiricharoengul SLwin TSharova TTarantino GLiu DCohen SfalseFactors Affecting Recurrence and Survival for Patients with High-Risk Stage II Melanoma.<h4>Background</h4>In the current era of effective adjuvant therapies and de-escalation of surgery, distinguishing which patients with high-risk stage II melanoma are at increased risk of recurrence after excision of the primary lesion is essential to determining appropriate treatment and surveillance plans.<h4>Methods</h4>A single-center retrospective study analyzed patients with stage IIB or IIC melanoma. Demographic and tumor data were collected, and genomic analysis of formalin-fixed, paraffin-embedded tissue samples was performed via an internal next-generation sequencing (NGS) platform (SNaPshot). The end points examined were relapse-free survival (RFS), distant metastasis-free survival (DMFS), overall survival (OS), and melanoma-specific survival (MSS). Uni- and multivariable Cox re2023-01-01T00:00:00Z2023 Dec2025-04-18T14:47:58.854Z2025-04-07T01:06:27.252ZS-EPMC109086403815849710.1245/s10434-023-14724-5