{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45"],"submitter":["Tian L"],"pubmed_abstract":["<h4>Background</h4>Dry eye disease has a high prevalence and exerts a significant negative effect on quality of life. In China, there are currently no available nasal sprays to promote natural tear production in patients with dry eye disease. We therefore evaluated the efficacy and safety of OC-01 (varenicline solution) nasal spray versus vehicle in Chinese patients with dry eye disease.<h4>Methods</h4>This was a randomized, multicenter, double-masked, vehicle-controlled, phase 3 clinical trial conducted at ophthalmology departments in 20 hospitals across China (NCT05378945). Eligible patients had a diagnosis of dry eye disease based on patient symptoms, Eye Dryness Score (EDS), Schirmer's Test (with topical anesthesia) Score (STS), and corneal fluorescein staining (CFS) score. Participant"],"journal":["The Lancet regional health. Western Pacific"],"pagination":["101032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10909742"],"repository":["biostudies-literature"],"pubmed_title":["Varenicline solution nasal spray for dry eye disease in Chinese patients: a randomized phase 3 trial."],"pmcid":["PMC10909742"],"pubmed_authors":["Ding F","Ma L","Lu X","Zhang H","Fu Y","Zhang M","Zhang S","Wang J","Wang L","Zhao S","Gu H","Jie Y","Ren Q","Tian L","Jin X","Zeng Q","Tao L","Lu C","Li Z","Li S","Zhu L","Zhu Q","Xu Y","Dai H","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Varenicline solution nasal spray for dry eye disease in Chinese patients: a randomized phase 3 trial.","description":"<h4>Background</h4>Dry eye disease has a high prevalence and exerts a significant negative effect on quality of life. In China, there are currently no available nasal sprays to promote natural tear production in patients with dry eye disease. We therefore evaluated the efficacy and safety of OC-01 (varenicline solution) nasal spray versus vehicle in Chinese patients with dry eye disease.<h4>Methods</h4>This was a randomized, multicenter, double-masked, vehicle-controlled, phase 3 clinical trial conducted at ophthalmology departments in 20 hospitals across China (NCT05378945). Eligible patients had a diagnosis of dry eye disease based on patient symptoms, Eye Dryness Score (EDS), Schirmer's Test (with topical anesthesia) Score (STS), and corneal fluorescein staining (CFS) score. Participant","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-12T05:47:02.561Z","creation":"2025-04-19T22:04:29.663Z"},"accession":"S-EPMC10909742","cross_references":{"pubmed":["38440130"],"doi":["10.1016/j.lanwpc.2024.101032"]}}