{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Tang N"],"pubmed_abstract":["<h4>Background</h4>Acute lung injury (ALI)/severe acute respiratory distress syndrome (ARDS) is a serious clinical syndrome characterized by a high mortality rate. The pathophysiological mechanisms underlying ALI/ARDS remain incompletely understood. Considering the crucial role of immune infiltration and macrophage polarization in the pathogenesis of ALI/ARDS, this study aims to identify key genes associated with both ALI/ARDS and M1 macrophage polarization, employing a combination of bioinformatics and experimental approaches. The findings could potentially reveal novel biomarkers for the diagnosis and management of ALI/ARDS.<h4>Methods</h4>Gene expression profiles relevant to ALI were retrieved from the GEO database to identify co-upregulated differentially expressed genes (DEGs). GO and"],"journal":["Frontiers in immunology"],"pagination":["1344805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10909908"],"repository":["biostudies-literature"],"pubmed_title":["<i>CD274</i> (PD-L1) negatively regulates M1 macrophage polarization in ALI/ARDS."],"pmcid":["PMC10909908"],"pubmed_authors":["Yang G","Liu Z","Yang Y","Xie Y","Wang Q","Li C","Tang N","Huang JA"],"additional_accession":[]},"is_claimable":false,"name":"<i>CD274</i> (PD-L1) negatively regulates M1 macrophage polarization in ALI/ARDS.","description":"<h4>Background</h4>Acute lung injury (ALI)/severe acute respiratory distress syndrome (ARDS) is a serious clinical syndrome characterized by a high mortality rate. The pathophysiological mechanisms underlying ALI/ARDS remain incompletely understood. Considering the crucial role of immune infiltration and macrophage polarization in the pathogenesis of ALI/ARDS, this study aims to identify key genes associated with both ALI/ARDS and M1 macrophage polarization, employing a combination of bioinformatics and experimental approaches. The findings could potentially reveal novel biomarkers for the diagnosis and management of ALI/ARDS.<h4>Methods</h4>Gene expression profiles relevant to ALI were retrieved from the GEO database to identify co-upregulated differentially expressed genes (DEGs). GO and","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-16T04:50:50.456Z","creation":"2025-04-19T22:02:45.069Z"},"accession":"S-EPMC10909908","cross_references":{"pubmed":["38440722"],"doi":["10.3389/fimmu.2024.1344805"]}}