{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cousineau CM"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIAMS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["426-433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10909986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["Genetically diverse outbred mice allow for the study of genetic variation in the context of high dietary and environmental control. Using a machine learning approach, we investigated clinical and morphometric factors that associate with serum cholesterol levels in 840 genetically unique Diversity Outbred mice of both sexes (n = 417 male and 423 female), and on both a control chow (% kcals in diet: protein 22%, carbohydrate 62%, fat 16%, no cholesterol) and high fat high sucrose (% kcals in diet: protein 15%, carbohydrate 41%, fat 45%, 0.05% cholesterol). We find expected elevations of cholesterol in male mice, as well as in mice with elevated serum triglycerides and/or fed a high fat high sucrose diet. The third strongest predictor was serum calcium which correlated with serum cholesterol across both diets and sexes (r = 0.39-0.48) in both Diversity Outbred (P = 3.0 × 10<sup>-43</sup> ) and BXD (P = 0.005) mice. This is in-line with several human cohort studies which show associations between calcium and cholesterol, and calcium as an independent predictor of cardiovascular events."],"journal":["FEBS open bio"],"pubmed_title":["Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice."],"pmcid":["PMC10909986"],"funding_grant_id":["R01 DK107535","P30 DK089503","R01 GM070683","P30 DK020572","R01DK107535","R01GM070683","P30 AR069620"],"pubmed_authors":["Cousineau CM","Churchill GA","Bridges D","Loftus K"],"additional_accession":[]},"is_claimable":false,"name":"Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice.","description":"Genetically diverse outbred mice allow for the study of genetic variation in the context of high dietary and environmental control. Using a machine learning approach, we investigated clinical and morphometric factors that associate with serum cholesterol levels in 840 genetically unique Diversity Outbred mice of both sexes (n = 417 male and 423 female), and on both a control chow (% kcals in diet: protein 22%, carbohydrate 62%, fat 16%, no cholesterol) and high fat high sucrose (% kcals in diet: protein 15%, carbohydrate 41%, fat 45%, 0.05% cholesterol). We find expected elevations of cholesterol in male mice, as well as in mice with elevated serum triglycerides and/or fed a high fat high sucrose diet. The third strongest predictor was serum calcium which correlated with serum cholesterol across both diets and sexes (r = 0.39-0.48) in both Diversity Outbred (P = 3.0 × 10<sup>-43</sup> ) and BXD (P = 0.005) mice. This is in-line with several human cohort studies which show associations between calcium and cholesterol, and calcium as an independent predictor of cardiovascular events.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-16T04:51:00.944Z","creation":"2025-04-05T11:38:38.475Z"},"accession":"S-EPMC10909986","cross_references":{"pubmed":["38129969"],"doi":["10.1002/2211-5463.13757"]}}