biostudies-literatureUnknown15Hashimi MBackground: Cataract is one of the most prevalent causes of blindness worldwide. Whilst surgery is the primary treatment for cataracts, it is not always an available option, particularly in developing countries. Non-surgical methods of treatment would increase treatment availability for more patients. Several studies have investigated how topical application of oxysterols, such as lanosterol, may break down aggregated proteins and restore lens transparency. However, the results are conflicting and inconclusive. Aim: In this study, we focus on combining genetic evidence for associations between lanosterol related genetic variation and cataract to explore whether lanosterol is a potentially suitable drug treatment option. Method: Using data from 45,449 available cataractFrontiers in genetics1231521https://www.ebi.ac.uk/biostudies/studies/S-EPMC10910428biostudies-literatureUsing genetics to investigate the association between lanosterol and cataract.PMC10910428Day ACDrenos FHashimi MAmin HAZagkos LfalseUsing genetics to investigate the association between lanosterol and cataract.Background: Cataract is one of the most prevalent causes of blindness worldwide. Whilst surgery is the primary treatment for cataracts, it is not always an available option, particularly in developing countries. Non-surgical methods of treatment would increase treatment availability for more patients. Several studies have investigated how topical application of oxysterols, such as lanosterol, may break down aggregated proteins and restore lens transparency. However, the results are conflicting and inconclusive. Aim: In this study, we focus on combining genetic evidence for associations between lanosterol related genetic variation and cataract to explore whether lanosterol is a potentially suitable drug treatment option. Method: Using data from 45,449 available cataract2024-01-01T00:00:00Z20242026-06-01T21:26:15.749Z2025-04-19T22:04:16.877ZS-EPMC109104283844019010.3389/fgene.2024.1231521