{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20"],"submitter":["Hampton AS"],"pubmed_abstract":["Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species."],"journal":["Beilstein journal of organic chemistry"],"pagination":["460-469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10910478"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas."],"pmcid":["PMC10910478"],"pubmed_authors":["Hodgson DRW","Hampton AS","McDougald G","Sandford G","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas.","description":"Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-26T22:36:43.477Z","creation":"2025-04-06T17:15:19.322Z"},"accession":"S-EPMC10910478","cross_references":{"pubmed":["38440170"],"doi":["10.3762/bjoc.20.41"]}}