biostudies-literatureUnknown20Hampton ASSolutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species.Beilstein journal of organic chemistry460-469https://www.ebi.ac.uk/biostudies/studies/S-EPMC10910478biostudies-literatureSynthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas.PMC10910478Hodgson DRWHampton ASMcDougald GSandford GWang LfalseSynthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas.Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species.2024-01-01T00:00:00Z20242025-04-26T22:36:43.477Z2025-04-06T17:15:19.322ZS-EPMC109104783844017010.3762/bjoc.20.41