{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20"],"submitter":["Ying Z"],"pubmed_abstract":["Pseudallenes A and B (<b>1</b> and <b>2</b>), the new and rare examples of sulfur-containing ovalicin derivatives, along with three known analogues <b>3</b>-<b>5</b>, were isolated and identified from the culture extract of <i>Pseudallescheria boydii</i> CS-793, a fungus obtained from the deep-sea cold seep sediments. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis confirmed and established the structures and absolute configurations of compounds <b>1</b>-<b>3</b>, thus providing the first characterized crystal structure of an ovalicin-type sesquiterpenoid. In the antimicrobial assays, compounds <b>1</b>-<b>3</b> showed broad-spectrum inhibitory activities against several plant pathogens with MIC values ranging from 2 to 16 μg/mL."],"journal":["Beilstein journal of organic chemistry"],"pagination":["470-478"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10910587"],"repository":["biostudies-literature"],"pubmed_title":["Pseudallenes A and B, new sulfur-containing ovalicin sesquiterpenoid derivatives with antimicrobial activity from the deep-sea cold seep sediment-derived fungus <i>Pseudallescheria boydii</i> CS-793."],"pmcid":["PMC10910587"],"pubmed_authors":["Li X","Yang SQ","Wang BG","Li XM","Li HL","Ying Z","Meng LH"],"additional_accession":[]},"is_claimable":false,"name":"Pseudallenes A and B, new sulfur-containing ovalicin sesquiterpenoid derivatives with antimicrobial activity from the deep-sea cold seep sediment-derived fungus <i>Pseudallescheria boydii</i> CS-793.","description":"Pseudallenes A and B (<b>1</b> and <b>2</b>), the new and rare examples of sulfur-containing ovalicin derivatives, along with three known analogues <b>3</b>-<b>5</b>, were isolated and identified from the culture extract of <i>Pseudallescheria boydii</i> CS-793, a fungus obtained from the deep-sea cold seep sediments. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis confirmed and established the structures and absolute configurations of compounds <b>1</b>-<b>3</b>, thus providing the first characterized crystal structure of an ovalicin-type sesquiterpenoid. In the antimicrobial assays, compounds <b>1</b>-<b>3</b> showed broad-spectrum inhibitory activities against several plant pathogens with MIC values ranging from 2 to 16 μg/mL.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T21:26:21.176Z","creation":"2025-04-19T22:04:26.96Z"},"accession":"S-EPMC10910587","cross_references":{"pubmed":["38440169"],"doi":["10.3762/bjoc.20.42"]}}